TY - JOUR
T1 - Association of APOE ε4 allele with survival in amyotrophic lateral sclerosis
AU - Drory, Vivian E.
AU - Birnbaum, Miriam
AU - Korczyn, Amos D.
AU - Chapman, Joab
PY - 2001
Y1 - 2001
N2 - APOE ε4 allele is associated with poorer outcome in degenerative neurological diseases. Its role in amyotrophic lateral sclerosis (ALS) is still unclear. The aim of the present study was to further analyze the association of APOE ε4 allele with progression and survival of ALS. One hundred consecutive ALS patients (53 males) and 133 controls were genotyped for the APOE ε4 allele. The association of this allele with survival to death or tracheostomy was analyzed by Kaplan-Meier survival analysis. The frequency of the APOE ε4 allele in ALS patients was slightly higher (15.1%) than in the control group (10.9%). Patients with or without an APOE ε4 allele had a similar age of onset and frequency of bulbar onset. There was a significant shortening of the 50% probability of survival (by 32 months) in patients carrying the APOE ε4 allele (p = 0.03). In conclusion, carrying an APOE ε4 allele is a poor prognostic factor in ALS. This is compatible with a role of apolipoprotein on neuronal survival and repair.
AB - APOE ε4 allele is associated with poorer outcome in degenerative neurological diseases. Its role in amyotrophic lateral sclerosis (ALS) is still unclear. The aim of the present study was to further analyze the association of APOE ε4 allele with progression and survival of ALS. One hundred consecutive ALS patients (53 males) and 133 controls were genotyped for the APOE ε4 allele. The association of this allele with survival to death or tracheostomy was analyzed by Kaplan-Meier survival analysis. The frequency of the APOE ε4 allele in ALS patients was slightly higher (15.1%) than in the control group (10.9%). Patients with or without an APOE ε4 allele had a similar age of onset and frequency of bulbar onset. There was a significant shortening of the 50% probability of survival (by 32 months) in patients carrying the APOE ε4 allele (p = 0.03). In conclusion, carrying an APOE ε4 allele is a poor prognostic factor in ALS. This is compatible with a role of apolipoprotein on neuronal survival and repair.
KW - Amyotrophic lateral sclerosis
KW - Apolipoprotein E ε4 allele
KW - Motor neuron disease
UR - http://www.scopus.com/inward/record.url?scp=0035885774&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(01)00569-X
DO - 10.1016/S0022-510X(01)00569-X
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AN - SCOPUS:0035885774
SN - 0022-510X
VL - 190
SP - 17
EP - 20
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1-2
ER -