Association between serum apolipoprotein CII concentration and coronary heart disease

Yariv Gerber, Uri Goldbourt, Hofit Cohen, Dror Harats*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Apolipoprotein (Apo) CII plays an essential role in the metabolism of triglyceride-rich lipoproteins (TRLs) by activating lipoprotein lipase. Several studies have suggested that an abnormal concentration of Apo CII may serve as a marker for deficient TRL metabolism, a possible cause of coronary heart disease (CHD). The aim of the present study was to evaluate the association between Apo CII and the presence of CHD. Methods. A case-control study comparing 352 CHD patients and 395 controls was performed. Demographic, clinical, and laboratory characteristics were determined. Results. The CHD patients had a higher mean concentration of Apo CII than controls (5.3 mg/dl compared with 4.2 mg/dl, P < 0.001). Elevated serum Apo CII concentration was associated with CHD presence after adjustment for cardiovascular risk factors. The risk factor-adjusted odds ratio (OR) for CHD was 1.60 (95% CI: 1.31-1.94) per 1 mg/dl increment in Apo CII, compared with a risk factor-adjusted OR of 1.05 (95% CI: 0.85-1.32) per 40 mg/dl increment in triglyceride concentration. Conclusion. Increased serum concentration of Apo CII may represent a more sensitive marker of CHD than high serum concentration of triglycerides. Confirmation in cohort studies in required to establish or refute the role of elevated serum Apo CII as a risk factor for CHD.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalPreventive Medicine
Volume35
Issue number1
DOIs
StatePublished - 2002

Keywords

  • Apolipoprotein C
  • Case-control studies
  • Coronary heart disease
  • Risk factors
  • Triglycerides

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