TY - JOUR
T1 - Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways
AU - Frisch, A.
AU - Michaelovsky, E.
AU - Rockah, R.
AU - Amir, I.
AU - Hermesh, H.
AU - Laor, N.
AU - Fuchs, C.
AU - Zohar, J.
AU - Lerer, B.
AU - Buniak, S. F.
AU - Landa, S.
AU - Poyurovsky, M.
AU - Shapira, B.
AU - Weizman, R.
N1 - Funding Information:
We wish to thank the Chief Scientist of the Israel Ministry of Health and the Recanati Fund for Medical Research, Tel Aviv University, for supporting this research.
PY - 2000/5
Y1 - 2000/5
N2 - Obsessive-compulsive disorder (OCD) is a severe and disabling anxiety disorder with a marked genetic contribution. Pharmacological data indicated involvement of the serotonergic and dopaminergic systems. We studied the association between OCD and six candidate genes encoding important components of the serotonergic and dopaminergic pathways in 75 biologically unrelated patients and 172 ethnically matched controls (Ashkenazi and non-Ashkenazi Jews). Polymorphisms in the following genes were studied: tryptophan hydroxylase (TPH), serotonin 2A receptor (HTR2A), serotonin 2C receptor (HTR2C), serotonin transporter (5-HTT), dopamine receptor D4 (DRD4), and dopamine transporter (DAT1). The genotypic and allelic distribution of all polymorphisms tested did not show statistically significant differences between patients and controls. Our results suggest that these polymorphisms do not play a major role in the genetic predisposition to OCD, although a minor contribution cannot be ruled out. (C) 2000 Elsevier Science B.V.
AB - Obsessive-compulsive disorder (OCD) is a severe and disabling anxiety disorder with a marked genetic contribution. Pharmacological data indicated involvement of the serotonergic and dopaminergic systems. We studied the association between OCD and six candidate genes encoding important components of the serotonergic and dopaminergic pathways in 75 biologically unrelated patients and 172 ethnically matched controls (Ashkenazi and non-Ashkenazi Jews). Polymorphisms in the following genes were studied: tryptophan hydroxylase (TPH), serotonin 2A receptor (HTR2A), serotonin 2C receptor (HTR2C), serotonin transporter (5-HTT), dopamine receptor D4 (DRD4), and dopamine transporter (DAT1). The genotypic and allelic distribution of all polymorphisms tested did not show statistically significant differences between patients and controls. Our results suggest that these polymorphisms do not play a major role in the genetic predisposition to OCD, although a minor contribution cannot be ruled out. (C) 2000 Elsevier Science B.V.
KW - Dopamine D4 receptor (DRD4)
KW - Dopamine transporter (DAT1)
KW - Serotonin 2A receptor (HTR2A)
KW - Serotonin 2C receptor (HTR2C)
KW - Serotonin transporter (5-HTT)
KW - Tryptophan hydroxylase (TPH)
UR - http://www.scopus.com/inward/record.url?scp=0033995464&partnerID=8YFLogxK
U2 - 10.1016/S0924-977X(00)00071-7
DO - 10.1016/S0924-977X(00)00071-7
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AN - SCOPUS:0033995464
SN - 0924-977X
VL - 10
SP - 205
EP - 209
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 3
ER -