Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways

A. Frisch, E. Michaelovsky, R. Rockah, I. Amir, H. Hermesh, N. Laor, C. Fuchs, J. Zohar, B. Lerer, S. F. Buniak, S. Landa, M. Poyurovsky, B. Shapira, R. Weizman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

Obsessive-compulsive disorder (OCD) is a severe and disabling anxiety disorder with a marked genetic contribution. Pharmacological data indicated involvement of the serotonergic and dopaminergic systems. We studied the association between OCD and six candidate genes encoding important components of the serotonergic and dopaminergic pathways in 75 biologically unrelated patients and 172 ethnically matched controls (Ashkenazi and non-Ashkenazi Jews). Polymorphisms in the following genes were studied: tryptophan hydroxylase (TPH), serotonin 2A receptor (HTR2A), serotonin 2C receptor (HTR2C), serotonin transporter (5-HTT), dopamine receptor D4 (DRD4), and dopamine transporter (DAT1). The genotypic and allelic distribution of all polymorphisms tested did not show statistically significant differences between patients and controls. Our results suggest that these polymorphisms do not play a major role in the genetic predisposition to OCD, although a minor contribution cannot be ruled out. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalEuropean Neuropsychopharmacology
Volume10
Issue number3
DOIs
StatePublished - May 2000

Funding

FundersFunder number
Tel Aviv University
Ministry of Health, State of Israel

    Keywords

    • Dopamine D4 receptor (DRD4)
    • Dopamine transporter (DAT1)
    • Serotonin 2A receptor (HTR2A)
    • Serotonin 2C receptor (HTR2C)
    • Serotonin transporter (5-HTT)
    • Tryptophan hydroxylase (TPH)

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