Association between diabetes mellitus and adverse characteristics of breast cancer at presentation

Ido Wolf; Siegal Sadetzki; Iris Gluck; Bernice Oberman; Merav Ben-David; Moshe Zvi Papa; Raphael Catane; Bella Kaufman

doi:10.1016/j.ejca.2006.01.027

Association between diabetes mellitus and adverse characteristics of breast cancer at presentation

Ido Wolf^*, Siegal Sadetzki, Iris Gluck, Bernice Oberman, Merav Ben-David, Moshe Zvi Papa, Raphael Catane, Bella Kaufman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Type 2 diabetes mellitus is associated with increased incidence and inferior outcome of various malignancies. The aim of this study was to explore the impact of type 2 diabetes on breast cancer characteristics at presentation. The study population included 79 diabetic and 158 age-matched non-diabetic patients. Parity, country of birth, co-morbidity other than diabetes, and mode of diagnosis were similar in both groups. Mean body mass index (BMI) was higher among diabetic patients. Tumour stage and size were higher among diabetic patients and the differences remained significant after adjustment for BMI. Moreover, after adjustment for BMI, breast cancer among diabetic patients was more often hormone receptor negative. Our results show that diabetes mellitus is associated with negative prognostic factors at breast cancer presentation.

Original language	English
Pages (from-to)	1077-1082
Number of pages	6
Journal	European Journal of Cancer
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.ejca.2006.01.027
State	Published - May 2006

Keywords

Breast cancer
Diabetes mellitus
Insulin
Oestrogen receptor
Progesterone receptor
Stage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2006.01.027

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title = "Association between diabetes mellitus and adverse characteristics of breast cancer at presentation",

abstract = "Type 2 diabetes mellitus is associated with increased incidence and inferior outcome of various malignancies. The aim of this study was to explore the impact of type 2 diabetes on breast cancer characteristics at presentation. The study population included 79 diabetic and 158 age-matched non-diabetic patients. Parity, country of birth, co-morbidity other than diabetes, and mode of diagnosis were similar in both groups. Mean body mass index (BMI) was higher among diabetic patients. Tumour stage and size were higher among diabetic patients and the differences remained significant after adjustment for BMI. Moreover, after adjustment for BMI, breast cancer among diabetic patients was more often hormone receptor negative. Our results show that diabetes mellitus is associated with negative prognostic factors at breast cancer presentation.",

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AU - Wolf, Ido

AU - Sadetzki, Siegal

AU - Gluck, Iris

AU - Oberman, Bernice

AU - Ben-David, Merav

AU - Papa, Moshe Zvi

AU - Catane, Raphael

AU - Kaufman, Bella

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AB - Type 2 diabetes mellitus is associated with increased incidence and inferior outcome of various malignancies. The aim of this study was to explore the impact of type 2 diabetes on breast cancer characteristics at presentation. The study population included 79 diabetic and 158 age-matched non-diabetic patients. Parity, country of birth, co-morbidity other than diabetes, and mode of diagnosis were similar in both groups. Mean body mass index (BMI) was higher among diabetic patients. Tumour stage and size were higher among diabetic patients and the differences remained significant after adjustment for BMI. Moreover, after adjustment for BMI, breast cancer among diabetic patients was more often hormone receptor negative. Our results show that diabetes mellitus is associated with negative prognostic factors at breast cancer presentation.

KW - Breast cancer

KW - Diabetes mellitus

KW - Insulin

KW - Oestrogen receptor

KW - Progesterone receptor

KW - Stage

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Association between diabetes mellitus and adverse characteristics of breast cancer at presentation

Abstract

Keywords

UN SDGs

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