TY - JOUR
T1 - Association between C-reactive protein level and echocardiography assessed left ventricular function in first ST-segment elevation myocardial infarction patients who underwent primary coronary intervention
AU - Shacham, Yacov
AU - Topilsky, Yan
AU - Leshem-Rubinow, Eran
AU - Arbel, Yaron
AU - Ben Assa, Eyal
AU - Keren, Gad
AU - Roth, Arie
AU - Steinvil, Arie
PY - 2014/6
Y1 - 2014/6
N2 - Background: An elevated C-reactive protein (CRP) level is associated with adverse outcomes in patients with acute myocardial infarction (AMI). Although CRP levels have been shown to be associated with left ventricular (LV) systolic function and remodeling in AMI, little is known about their relation to early LV diastolic function. Methods: We retrospectively studied 173 consecutive patients <75 years of age with first ST-segment elevation MI (STEMI) that was treated by primary percutaneous coronary intervention (PPCI). They had presented within 24. h of chest pain onset and their CRP levels were determined within 6. h of hospital admission. They all underwent echocardiography within 3 days of admission and were stratified by CRP tertiles. Results: The cut-off points for the CRP tertiles were <2.6. mg/L, 2.6-7.9. mg/L, and >7.9. mg/L. Patients with higher CRP levels had a significantly higher mean mitral inflow E wave velocity (68 ± 16. cm/s vs 77 ± 19. cm/s vs 76 ± 17. cm/s; p= 0.02), a higher E/average e' (8.9 ± 1.9 vs 9.8 ± 2.8 vs 10.4 ± 3.2; p= 0.02), and a higher systolic pulmonary artery pressure (27 ± 6. mmHg vs 30 ± 8. mmHg vs 32 ± 10. mmHg; p= 0.04). Elevated CRP levels were associated with more advanced diastolic dysfunction than normal CRP levels (p= 0.04). The admission CRP level was an independent predictor of average E/. e' ratio (multivariate analysis). Conclusion: Admission CRP levels are associated with echocardiographic parameters of elevated LV filling pressure in patients with STEMI treated with PPCI.
AB - Background: An elevated C-reactive protein (CRP) level is associated with adverse outcomes in patients with acute myocardial infarction (AMI). Although CRP levels have been shown to be associated with left ventricular (LV) systolic function and remodeling in AMI, little is known about their relation to early LV diastolic function. Methods: We retrospectively studied 173 consecutive patients <75 years of age with first ST-segment elevation MI (STEMI) that was treated by primary percutaneous coronary intervention (PPCI). They had presented within 24. h of chest pain onset and their CRP levels were determined within 6. h of hospital admission. They all underwent echocardiography within 3 days of admission and were stratified by CRP tertiles. Results: The cut-off points for the CRP tertiles were <2.6. mg/L, 2.6-7.9. mg/L, and >7.9. mg/L. Patients with higher CRP levels had a significantly higher mean mitral inflow E wave velocity (68 ± 16. cm/s vs 77 ± 19. cm/s vs 76 ± 17. cm/s; p= 0.02), a higher E/average e' (8.9 ± 1.9 vs 9.8 ± 2.8 vs 10.4 ± 3.2; p= 0.02), and a higher systolic pulmonary artery pressure (27 ± 6. mmHg vs 30 ± 8. mmHg vs 32 ± 10. mmHg; p= 0.04). Elevated CRP levels were associated with more advanced diastolic dysfunction than normal CRP levels (p= 0.04). The admission CRP level was an independent predictor of average E/. e' ratio (multivariate analysis). Conclusion: Admission CRP levels are associated with echocardiographic parameters of elevated LV filling pressure in patients with STEMI treated with PPCI.
KW - Acute myocardial infarction
KW - C-reactive protein
KW - Left ventricle diastolic function
UR - http://www.scopus.com/inward/record.url?scp=84902146882&partnerID=8YFLogxK
U2 - 10.1016/j.jjcc.2013.10.013
DO - 10.1016/j.jjcc.2013.10.013
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AN - SCOPUS:84902146882
SN - 0914-5087
VL - 63
SP - 402
EP - 408
JO - Journal of Cardiology
JF - Journal of Cardiology
IS - 6
ER -