Association between C-reactive protein level and echocardiography assessed left ventricular function in first ST-segment elevation myocardial infarction patients who underwent primary coronary intervention

Yacov Shacham, Yan Topilsky, Eran Leshem-Rubinow, Yaron Arbel, Eyal Ben Assa, Gad Keren, Arie Roth, Arie Steinvil

Research output: Contribution to journalArticlepeer-review

Abstract

Background: An elevated C-reactive protein (CRP) level is associated with adverse outcomes in patients with acute myocardial infarction (AMI). Although CRP levels have been shown to be associated with left ventricular (LV) systolic function and remodeling in AMI, little is known about their relation to early LV diastolic function. Methods: We retrospectively studied 173 consecutive patients <75 years of age with first ST-segment elevation MI (STEMI) that was treated by primary percutaneous coronary intervention (PPCI). They had presented within 24. h of chest pain onset and their CRP levels were determined within 6. h of hospital admission. They all underwent echocardiography within 3 days of admission and were stratified by CRP tertiles. Results: The cut-off points for the CRP tertiles were <2.6. mg/L, 2.6-7.9. mg/L, and >7.9. mg/L. Patients with higher CRP levels had a significantly higher mean mitral inflow E wave velocity (68 ± 16. cm/s vs 77 ± 19. cm/s vs 76 ± 17. cm/s; p= 0.02), a higher E/average e' (8.9 ± 1.9 vs 9.8 ± 2.8 vs 10.4 ± 3.2; p= 0.02), and a higher systolic pulmonary artery pressure (27 ± 6. mmHg vs 30 ± 8. mmHg vs 32 ± 10. mmHg; p= 0.04). Elevated CRP levels were associated with more advanced diastolic dysfunction than normal CRP levels (p= 0.04). The admission CRP level was an independent predictor of average E/. e' ratio (multivariate analysis). Conclusion: Admission CRP levels are associated with echocardiographic parameters of elevated LV filling pressure in patients with STEMI treated with PPCI.

Original languageEnglish
Pages (from-to)402-408
Number of pages7
JournalJournal of Cardiology
Volume63
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Acute myocardial infarction
  • C-reactive protein
  • Left ventricle diastolic function

Fingerprint

Dive into the research topics of 'Association between C-reactive protein level and echocardiography assessed left ventricular function in first ST-segment elevation myocardial infarction patients who underwent primary coronary intervention'. Together they form a unique fingerprint.

Cite this