TY - JOUR
T1 - Association between anorexia nervosa and the hsKCa3 gene
T2 - A family-based and case control study
AU - Koronyo-Hamaoui, M.
AU - Danziger, Y.
AU - Frisch, A.
AU - Stein, D.
AU - Leor, S.
AU - Laufer, N.
AU - Carel, C.
AU - Fennig, S.
AU - Minoumi, M.
AU - Apter, A.
AU - Goldman, B.
AU - Barkai, G.
AU - Weizman, A.
AU - Gak, E.
N1 - Funding Information:
This study was supported by a grant (No. 610–212.02) from the German-Israeli Foundation for Scientific Research and Development. The authors thank Gloria Ginzach and Melanie Kawe for their editorial and secretarial help.
PY - 2002
Y1 - 2002
N2 - Familial and twin studies have suggested that anorexia nervosa (AN) is a multifactorial disorder with a substantial genetic contribution. The hSKCa3 potassium channel gene, which contains polymorphic CAG repeats in the coding region and is involved in the regulation of neuronal activity, may be a candidate gene for AN because alleles with longer repeats have been found to be associated with mental disorders. Forty Israeli AN family trios were genotyped for the hSKCa3 CAG repeat polymorphism using the haplotype relative risk (HRR) method. The distribution of alleles transmitted to the patients was found to be significantly different from that of the non-transmitted parental alleles, with the longer alleles being over-represented in the patients (Wilcoxon rank test, P = 0.008). The transmission disequilibrium test (TDT) revealed that longer (>19) repeat alleles were preferentially transmitted to AN patients (McNemar's x2 = 10.31, P = 0.0013). These results were corroborated by comparing the distribution of alleles between patients and healthy controls (Mann-Whitney test, P = 0.005). Our study suggests that the longer repeat alleles of the hSKCa3 gene may contribute to the genetic susceptibility to AN.
AB - Familial and twin studies have suggested that anorexia nervosa (AN) is a multifactorial disorder with a substantial genetic contribution. The hSKCa3 potassium channel gene, which contains polymorphic CAG repeats in the coding region and is involved in the regulation of neuronal activity, may be a candidate gene for AN because alleles with longer repeats have been found to be associated with mental disorders. Forty Israeli AN family trios were genotyped for the hSKCa3 CAG repeat polymorphism using the haplotype relative risk (HRR) method. The distribution of alleles transmitted to the patients was found to be significantly different from that of the non-transmitted parental alleles, with the longer alleles being over-represented in the patients (Wilcoxon rank test, P = 0.008). The transmission disequilibrium test (TDT) revealed that longer (>19) repeat alleles were preferentially transmitted to AN patients (McNemar's x2 = 10.31, P = 0.0013). These results were corroborated by comparing the distribution of alleles between patients and healthy controls (Mann-Whitney test, P = 0.005). Our study suggests that the longer repeat alleles of the hSKCa3 gene may contribute to the genetic susceptibility to AN.
KW - CAG repeats
KW - Eating disorders
KW - Haplotype relative risk (HRR)
KW - Polymorphism
KW - Transmission disequilibrium test (TDT)
KW - hSKCa3 (KCNN3)
UR - http://www.scopus.com/inward/record.url?scp=85047700258&partnerID=8YFLogxK
U2 - 10.1038/sj.mp.4000931
DO - 10.1038/sj.mp.4000931
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 11803450
AN - SCOPUS:85047700258
SN - 1359-4184
VL - 7
SP - 82
EP - 85
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 1
ER -
