@article{aa71f3a77afa42c1ae48f3551e94360e,
title = "Assessment of the use of sialogogues in the clinical management of patients with xerostomia",
abstract = "This study was conducted to assess the clinical efficacy and adverse effects of pilocarpine, bethanechol and cevimeline in patients with xerostomia. In this open-label crossover assessment in 20 patients with xerostomia, a one- to two-week course of each medication with a one-week washout period was prescribed. Side effects, symptoms, whole stimulated and unstimulated saliva were measured. Each sialogogue was found to increase saliva and decrease symptoms. A mixed-effects analysis showed a greater increase in stimulated saliva on bethanechol compared to pilocarpine (0.106, p=0.0272). Increased sweating was the most common side effect, experienced more frequently with pilocarpine as compared to bethanechol (p=0.0588) or cevimeline (p= 0.0143). A carryover effect beyond the washout period was seen. Effects on saliva and side effects vary between sialogogues, suggesting a benefit of trials with different sialogogues to determine individual patient preference. The observed carryover effect suggests that intermittent treatment may be an alternative to continuous treatment with sialogogues.",
keywords = "Bethanechol, Cevimeline, Dry mouth, Pilocarpine, Sialogogue, Xerostomia",
author = "Nita Chainani-Wu and Meir Gorsky and Priscilla Mayer and Alan Bostrom and Epstein, {Joel B.} and Sol Silverman",
year = "2006",
month = jul,
doi = "10.1111/j.1754-4505.2006.tb01719.x",
language = "אנגלית",
volume = "26",
pages = "164--170",
journal = "Special Care in Dentistry",
issn = "0275-1879",
publisher = "Wiley-Blackwell",
number = "4",
}