Assessment of neurolymphomatosis by brachial plexus biopsy and PET/CT. Report of a case

Objective: To report a biopsy-proven neurolymphomatosis in a young woman with previous non-Hodgkin's lymphoma (NHL) of uterine cervix. Patient: The patient presented with a painful brachial plexopathy and developed multiple cranial and spinal nerve palsies. Methods and results: The diagnosis was achieved by an open brachial plexus biopsy. A PET/CT study was used to assess the full extent of the disease and showed involvement of additional cranial nerves and spinal nerve roots. A complete although short lasting clinical and radiological response was achieved by means of systemic high dose methotrexate treatment combined with rituximab and intra-CSF injections of cytarabine.