Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI

Maya Dadiani; Nir Kahana; Bella Kaufman; Eli Konen; Miri Sklair-Levy; Arnaldo Mayer

doi:10.1109/IST.2016.7738221

Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI

Maya Dadiani, Nir Kahana, Bella Kaufman, Eli Konen, Miri Sklair-Levy, Arnaldo Mayer

Diagnostic Imaging

Sheba Medical Center at Tel Hashomer

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Interstitial Fluid Pressure (IFP) is a major obstacle to intra-tumoral drug delivery. A routine non-invasive assessment of IFP will serve as a valuable predictor for the response to neoadjuvant treatment in breast cancer. It will also be the basis for a rationalized and personalized therapy by improving the efficacy of anti-cancer therapeutics via reduction of tumor IFP. We developed an automated robust algorithm for assessing IFP based on image analysis of dynamic contrast-enhanced MRI (DCE-MRI) examinations. This method is easy to implement on any MRI dataset of breast cancer and does not require any input from the radiologist besides delineating the tumor region.

Original language	English
Title of host publication	IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	189-194
Number of pages	6
ISBN (Electronic)	9781509018178
DOIs	https://doi.org/10.1109/IST.2016.7738221
State	Published - 7 Nov 2016
Event	2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016 - Chania, Crete Island, Greece Duration: 4 Oct 2016 → 6 Oct 2016

Publication series

Name	IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings

Conference

Conference	2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016
Country/Territory	Greece
City	Chania, Crete Island
Period	4/10/16 → 6/10/16

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/IST.2016.7738221

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Dadiani, M., Kahana, N., Kaufman, B., Konen, E., Sklair-Levy, M., & Mayer, A. (2016). Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI. In IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings (pp. 189-194). Article 7738221 (IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IST.2016.7738221

Dadiani, Maya ; Kahana, Nir ; Kaufman, Bella et al. / Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI. IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. pp. 189-194 (IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings).

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abstract = "Interstitial Fluid Pressure (IFP) is a major obstacle to intra-tumoral drug delivery. A routine non-invasive assessment of IFP will serve as a valuable predictor for the response to neoadjuvant treatment in breast cancer. It will also be the basis for a rationalized and personalized therapy by improving the efficacy of anti-cancer therapeutics via reduction of tumor IFP. We developed an automated robust algorithm for assessing IFP based on image analysis of dynamic contrast-enhanced MRI (DCE-MRI) examinations. This method is easy to implement on any MRI dataset of breast cancer and does not require any input from the radiologist besides delineating the tumor region.",

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Dadiani, M, Kahana, N, Kaufman, B , Konen, E , Sklair-Levy, M & Mayer, A 2016, Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI. in IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings., 7738221, IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 189-194, 2016 IEEE International Conference on Imaging Systems and Techniques, IST 2016, Chania, Crete Island, Greece, 4/10/16. https://doi.org/10.1109/IST.2016.7738221

Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI. / Dadiani, Maya; Kahana, Nir; Kaufman, Bella et al.
IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2016. p. 189-194 7738221 (IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Interstitial Fluid Pressure (IFP) is a major obstacle to intra-tumoral drug delivery. A routine non-invasive assessment of IFP will serve as a valuable predictor for the response to neoadjuvant treatment in breast cancer. It will also be the basis for a rationalized and personalized therapy by improving the efficacy of anti-cancer therapeutics via reduction of tumor IFP. We developed an automated robust algorithm for assessing IFP based on image analysis of dynamic contrast-enhanced MRI (DCE-MRI) examinations. This method is easy to implement on any MRI dataset of breast cancer and does not require any input from the radiologist besides delineating the tumor region.

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Dadiani M, Kahana N, Kaufman B , Konen E , Sklair-Levy M , Mayer A. Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI. In IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings. Institute of Electrical and Electronics Engineers Inc. 2016. p. 189-194. 7738221. (IST 2016 - 2016 IEEE International Conference on Imaging Systems and Techniques, Proceedings). doi: 10.1109/IST.2016.7738221

Assessment of Interstitial Fluid Pressure in solid tumors via image processing of DCE-MRI

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