Assessment of combined 24,25(oh)2d3 and 1α(oh)d3 therapy for bone disease in dialysis patients

M. M. Popovtzer*, J. Levi, Y. Bar-Khayim, S. M. Shasha, G. Boner, J. Bernheim, C. Chaimovitz, D. Rubinger, U. Gafter, D. Gazit, S. Edelstein, E. Slatopolsky, B. Z. Weiner, D. R. Kafka, S. Kadosh, D. Ladkani, Z. Mazor, B. Shalita, I. Bab

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

An increasing body of experimental data suggests a role for 24,25(OH)2D3 in bone metabolism. The present study was carried out to assess a possible therapeutic role of this vitamin D metabolite in renal osteodystrophy. Twenty-two chronic dialysis patients, most of whom were previously maintained on 1α(OH)D3 therapy, received additional treatment with 10 μg/day 24,25(OH)2D3 and were compared to 19 patients receiving 1α(OH)D3 alone. Analysis of transiliac bone biopsies obtained at study entry and following 10-16 months of treatment revealed that the combined therapy produced a decrease in bone turnover. Specifically, the addition of 24,25(OH)2D3 inhibited an increase in trabecular bone volume ( BV TV) and suppressed osteoclastic parameters. Thus BV TV increased from 26.2 ± 8.6 to 32.1 ± 7.5% (p < 0.01) in the 1α(OH)D3 group, but it remained unchanged in the combined therapy group. In contrast, the eroded surface ( ES BS), the osteoclast surface ( Oc.S BS), and the osteoclast numbers were significantly suppressed in patients receiving both 24,25(OH)2D3 and 1α(OH)D3, as compared with those receiving 1α(OH)D3 alone (p < 0.01, p < 0.01, and p < 0.001, respectively). These improvements were independent of changes in 1α(OH)D3 dosage. The extent of bone aluminium deposits was unrelated to the administration of 24,25-(OH)2D3 or to its effect. 24,25(OH)2D3 therapy was not associated with any adverse effects.

Original languageEnglish
Pages (from-to)369-377
Number of pages9
JournalBone
Volume13
Issue number5
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • 1α(OH)D
  • 24,25-(OH)D
  • Aluminium
  • Bone biopsy
  • Dialysis
  • Renal osteodystrophy

Fingerprint

Dive into the research topics of 'Assessment of combined 24,25(oh)2d3 and 1α(oh)d3 therapy for bone disease in dialysis patients'. Together they form a unique fingerprint.

Cite this