Assessment of Cognitive Function in Systemic Lupus Erythematosus

Kimberley Yuen, Mahta Kakvan, Oshrat E. Tayer-Shifman, Nathalie Rozenbojm, Kathleen Bingham, Zahi Touma*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Cognitive impairment (CI) is common in patients with systemic lupus erythematosus (SLE), with a pooled prevalence of 38% (95% confidence interval: 33–43%). While common, screening and diagnosing CI can be challenging. Cognitive impairment is often associated with physiological and psychological factors that can greatly impact the quality of life of patients with SLE. This chapter covers several topics under the umbrella of cognitive functioning in patients with SLE, including an overview of the definition and prevalence of CI in patients with SLE, instruments for measuring cognitive function, the ongoing heterogeneity of CI definition and assessment in patients with SLE, changes in cognition over time, the association between cognition and other comorbidities such as depression and anxiety, the relationship between cognition and patient health-related quality of life, and the association between cytokines and antibodies in relation to cognition.

Original languageEnglish
Title of host publicationOutcome Measures and Metrics in Systemic Lupus Erythematosus
PublisherSpringer International Publishing
Number of pages35
ISBN (Electronic)9783030733032
ISBN (Print)9783030733025
StatePublished - 1 Jan 2021
Externally publishedYes


  • Antibodies
  • Anxiety
  • Cognitive impairment
  • Cytokines
  • Depression
  • Health-related quality of life
  • Neuropsychological measurement
  • Systemic lupus erythematosus


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