TY - JOUR
T1 - Aspirin inhibits Ca2t+-stimulated fatty acid release from human washed platelets
AU - Pilo, Raphael
AU - Raz, Amiram
N1 - Funding Information:
This research was supported by a grant from the U.S. - Israel Binational Science Foundation (BSF), Jerusalem, Israel.
PY - 1981/6
Y1 - 1981/6
N2 - Ca2+ at 2mM concentration stimulates the release of saturated and unsaturated fatty acids from intact washed platelets incubated at 37°C with stirring. Aspirin at a concentration of 0.4mM inhibits both cyclo-oxygenase activity and fatty acid efflux induced by Cat+. Thus, in intact washed platelets, aspirin reduces formation of cyclo-oxygenase products by direct inhibition of the enzyme and by reducing the availability of precursor arachidonate.
AB - Ca2+ at 2mM concentration stimulates the release of saturated and unsaturated fatty acids from intact washed platelets incubated at 37°C with stirring. Aspirin at a concentration of 0.4mM inhibits both cyclo-oxygenase activity and fatty acid efflux induced by Cat+. Thus, in intact washed platelets, aspirin reduces formation of cyclo-oxygenase products by direct inhibition of the enzyme and by reducing the availability of precursor arachidonate.
UR - http://www.scopus.com/inward/record.url?scp=0019390932&partnerID=8YFLogxK
U2 - 10.1016/0161-4630(81)90128-2
DO - 10.1016/0161-4630(81)90128-2
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AN - SCOPUS:0019390932
SN - 0161-4630
VL - 6
SP - 657
EP - 660
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 6
ER -