Aspirin inhibits Ca2t+-stimulated fatty acid release from human washed platelets

Raphael Pilo, Amiram Raz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Ca2+ at 2mM concentration stimulates the release of saturated and unsaturated fatty acids from intact washed platelets incubated at 37°C with stirring. Aspirin at a concentration of 0.4mM inhibits both cyclo-oxygenase activity and fatty acid efflux induced by Cat+. Thus, in intact washed platelets, aspirin reduces formation of cyclo-oxygenase products by direct inhibition of the enzyme and by reducing the availability of precursor arachidonate.

Original languageEnglish
Pages (from-to)657-660
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume6
Issue number6
DOIs
StatePublished - Jun 1981

Funding

FundersFunder number
United States-Israel Binational Science Foundation

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