Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries

Anat Bar-Shira, Carolyn M. Hutter, Nir Giladi, Cyrus P. Zabetian, Avi Orr-Urtreger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The LRRK2 G2019S mutation is a major genetic determinant of Parkinson's disease (PD) across the world that occurs at an elevated frequency in Ashkenazi Jews. We determined the LRRK2 haplotypes in 77 G2019S carriers, mostly Ashkenazi Jews, and in 50 noncarrier Ashkenazi PD patients, using 16 genetic markers. A single haplotype was detected in all mutation carriers, indicating that these individuals share a common founder. Using a maximumlikelihood method, we estimate that Ashkenazi Jews with G2019S share a common ancestor who lived ~1,830 (95% CI 1,560-2,160) years ago, around the second century, after the second Jewish Diaspora.

Original languageEnglish
Pages (from-to)355-358
Number of pages4
JournalNeurogenetics
Volume10
Issue number4
DOIs
StatePublished - 2009

Funding

FundersFunder number
Miami
Wolfson and Kahn Foundations
National Parkinson Foundation

    Keywords

    • Ashkenazi jews
    • Founder mutation
    • Haplotype
    • LRRK2 G2019S mutation
    • Parkinson's disease

    Fingerprint

    Dive into the research topics of 'Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries'. Together they form a unique fingerprint.

    Cite this