@article{ab63587a9a364c6bbdf0c38e5be3474a,
title = "Ashkenazi Parkinson's disease patients with the LRRK2 G2019S mutation share a common founder dating from the second to fifth centuries",
abstract = "The LRRK2 G2019S mutation is a major genetic determinant of Parkinson's disease (PD) across the world that occurs at an elevated frequency in Ashkenazi Jews. We determined the LRRK2 haplotypes in 77 G2019S carriers, mostly Ashkenazi Jews, and in 50 noncarrier Ashkenazi PD patients, using 16 genetic markers. A single haplotype was detected in all mutation carriers, indicating that these individuals share a common founder. Using a maximumlikelihood method, we estimate that Ashkenazi Jews with G2019S share a common ancestor who lived ~1,830 (95% CI 1,560-2,160) years ago, around the second century, after the second Jewish Diaspora.",
keywords = "Ashkenazi jews, Founder mutation, Haplotype, LRRK2 G2019S mutation, Parkinson's disease",
author = "Anat Bar-Shira and Hutter, {Carolyn M.} and Nir Giladi and Zabetian, {Cyrus P.} and Avi Orr-Urtreger",
note = "Funding Information: The assistance of Dr. Helena Yagev-More is gratefully acknowledged. This work was supported by grants from National Parkinson Foundation, Miami, USA, Tel Aviv Sourasky Medical Center Grant of Excellence, and Wolfson and Kahn Foundations. ",
year = "2009",
doi = "10.1007/s10048-009-0186-0",
language = "אנגלית",
volume = "10",
pages = "355--358",
journal = "Neurogenetics",
issn = "1364-6745",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "4",
}