Ascorbic acid-induced regression of amyloidosis in experimental animals

M. Ravid, B. Chen, J. Bernheim, I. Kedar

Research output: Contribution to journalArticlepeer-review


Ascorbic acid was found to accelerate amyloid degradation in an experimental animal model. Based on experiments on vitro which demonstrated the ability of ascorbic acid to restore the amyloid-degrading activity of amyloidotic human serum, the effect of orally administered ascorbic acid was tested in casein-induced murine amyloidosis. Histopathological examination of splenic tissue of mice killed at different times after the termination of the amyloidogenic stimulus showed a markedly decreased amyloid deposition in ascorbic acid-treated animals as compared to the controls. The effect of ascorbic acid was to a certain degree dose-dependent. Colchicine blocked amyloid synthesis when administered during amyloid induction. In animals which were given the drug during the post-induction period it had no effect. The amyloid-degrading activity of mouse serum was reduced in amyloidotic mice. Administration of ascorbic acid partially restored the amyloid-degrading activity of these animals.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalBritish Journal of Experimental Pathology
Issue number2
StatePublished - 1985
Externally publishedYes


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