TY - JOUR
T1 - Ascorbic acid for the treatment of methemoglobinemia
T2 - The experience of a large tertiary care pediatric hospital
AU - Rino, Pedro Bonifacio
AU - Scolnik, Dennis
AU - Fustiñana, Ana
AU - Mitelpunkt, Alexis
AU - Glatstein, Miguel
PY - 2014
Y1 - 2014
N2 - The purpose of reporting this series of patients is to illustrate the role of ascorbic acid in the treatment of severe acquired methemoglobinemia (metHb), especially when methylene blue is not available. Medical records of affected patients were reviewed to collect history of exposures, food ingestion, physical examination, pulse oximetry, blood gas, and co-oximetry results, and outcomes. Five cases of acquired metHb are presented here, all of whom received treatment with ascorbic acid and fully recovered after 24 hours of treatment. Our series emphasizes that ascorbic acid is an effective alternative in the management of acquired metHb if methylene blue is unavailable and suggests that ascorbic acid infusion may be indicated in patients with glucose-6-phosphatase dehydrogenase deficiency.
AB - The purpose of reporting this series of patients is to illustrate the role of ascorbic acid in the treatment of severe acquired methemoglobinemia (metHb), especially when methylene blue is not available. Medical records of affected patients were reviewed to collect history of exposures, food ingestion, physical examination, pulse oximetry, blood gas, and co-oximetry results, and outcomes. Five cases of acquired metHb are presented here, all of whom received treatment with ascorbic acid and fully recovered after 24 hours of treatment. Our series emphasizes that ascorbic acid is an effective alternative in the management of acquired metHb if methylene blue is unavailable and suggests that ascorbic acid infusion may be indicated in patients with glucose-6-phosphatase dehydrogenase deficiency.
KW - ascorbic acid
KW - infants
KW - methemoglobinemia
KW - methylene blue
UR - http://www.scopus.com/inward/record.url?scp=84904262026&partnerID=8YFLogxK
U2 - 10.1097/MJT.0000000000000028
DO - 10.1097/MJT.0000000000000028
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C2 - 24914501
AN - SCOPUS:84904262026
SN - 1075-2765
VL - 21
SP - 240
EP - 243
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
IS - 4
ER -