@article{51767ba5cbc044a081edeb80fc4d413e,
title = "ARTS: Alignment of RNA tertiary structures",
abstract = "Motivation: A fast growing number of non-coding RNAs have recently been discovered to play essential roles in many cellular processes. Similar to proteins, understanding the functions of these active RNAs requires methods for analyzing their tertiary structures. However, in contrast to the wide range of structure-based approaches available for proteins, there is still a lack of methods for studying RNA structures. Results: We present a new computational method named ARTS (alignment of RNA tertiary structures). The method compares two nucleic acid structures (RNAs or DNAs) and detects a-priori unknown common substructures. These substructures can be either large global folds containing hundreds and even thousands of nucleotides or small local tertiary motifs with at least two successive base pairs. To the best of our knowledge, this is the first method of this type. The method is highly-efficient and was used to conduct an all-against-all comparison of all the RNA structures currently available in the Protein Data Bank.",
author = "Oranit Dror and Ruth Nussinov and Haim Wolfson",
note = "Funding Information: We thank Maxim Shatsky for stimulating discussions. The research of H.J.W. is partially supported by the Hermann Minkowski-Minerva Center for Geometry at TAU. The research of R.N. has been funded in whole or in part with Federal funds from the NCI, NIH, under contract number NO1-CO-12400. The content of this publication does not necessarily reflect the view or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organization imply endorsement by the US Government.",
year = "2005",
month = sep,
doi = "10.1093/bioinformatics/bti1108",
language = "אנגלית",
volume = "21",
pages = "ii47--ii53",
journal = "Bioinformatics",
issn = "1367-4803",
publisher = "Oxford University Press",
number = "SUPPL. 2",
}