Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

Marie Wetterslev; Robert GW Lambert; Walter P. Maksymowych; Iris Eshed; Susanne J. Pedersen; Paul Bird; Maria S. Stoenoiu; Simon Krabbe; Ashish J. Mathew; Violaine Foltz; Frédérique Gandjbakhch; Joel Paschke; Gabriele De Marco; Helena Marzo-Ortega; Philippe Carron; Anna EF Poulsen; Jacob L. Jaremko; Philip G. Conaghan; Mikkel Østergaard

doi:10.1016/j.semarthrit.2021.05.006

Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

Marie Wetterslev^*, Robert GW Lambert, Walter P. Maksymowych, Iris Eshed, Susanne J. Pedersen, Paul Bird, Maria S. Stoenoiu, Simon Krabbe, Ashish J. Mathew, Violaine Foltz, Frédérique Gandjbakhch, Joel Paschke, Gabriele De Marco, Helena Marzo-Ortega, Philippe Carron, Anna EF Poulsen, Jacob L. Jaremko, Philip G. Conaghan, Mikkel Østergaard

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis. Methods: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS). Results: In exercises 3–4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58–0.65 (WIPE-osteitis), 0.10–0.88 (HIMRISS-osteitis) and for status/change 0.38–0.72/0.52–0.60 (WIPE-synovitis/effusion) and 0.68–0.89/0.78–0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS. Conclusion: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.

Original language	English
Pages (from-to)	940-945
Number of pages	6
Journal	Seminars in Arthritis and Rheumatism
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.semarthrit.2021.05.006
State	Published - Aug 2021

Keywords

HIMRISS
Hip
MRI-WIPE
OMERACT
Spondyloarthritis
Whole-body MRI

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10.1016/j.semarthrit.2021.05.006

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Wetterslev, M., Lambert, R. GW., Maksymowych, W. P., Eshed, I., Pedersen, S. J., Bird, P., Stoenoiu, M. S., Krabbe, S., Mathew, A. J., Foltz, V., Gandjbakhch, F., Paschke, J., De Marco, G., Marzo-Ortega, H., Carron, P., Poulsen, A. EF., Jaremko, J. L., Conaghan, P. G., & Østergaard, M. (2021). Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods. Seminars in Arthritis and Rheumatism, 51(4), 940-945. https://doi.org/10.1016/j.semarthrit.2021.05.006

@article{3efc08df639d492492082efca5fad1ab,

title = "Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods",

abstract = "Objective: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis. Methods: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS). Results: In exercises 3–4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58–0.65 (WIPE-osteitis), 0.10–0.88 (HIMRISS-osteitis) and for status/change 0.38–0.72/0.52–0.60 (WIPE-synovitis/effusion) and 0.68–0.89/0.78–0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS. Conclusion: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.",

keywords = "HIMRISS, Hip, MRI-WIPE, OMERACT, Spondyloarthritis, Whole-body MRI",

author = "Marie Wetterslev and Lambert, {Robert GW} and Maksymowych, {Walter P.} and Iris Eshed and Pedersen, {Susanne J.} and Paul Bird and Stoenoiu, {Maria S.} and Simon Krabbe and Mathew, {Ashish J.} and Violaine Foltz and Fr{\'e}d{\'e}rique Gandjbakhch and Joel Paschke and {De Marco}, Gabriele and Helena Marzo-Ortega and Philippe Carron and Poulsen, {Anna EF} and Jaremko, {Jacob L.} and Conaghan, {Philip G.} and Mikkel {\O}stergaard",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = aug,

doi = "10.1016/j.semarthrit.2021.05.006",

language = "אנגלית",

volume = "51",

pages = "940--945",

journal = "Seminars in Arthritis and Rheumatism",

issn = "0049-0172",

publisher = "W.B. Saunders Ltd",

number = "4",

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Wetterslev, M, Lambert, RGW, Maksymowych, WP, Eshed, I, Pedersen, SJ, Bird, P, Stoenoiu, MS, Krabbe, S, Mathew, AJ, Foltz, V, Gandjbakhch, F, Paschke, J, De Marco, G, Marzo-Ortega, H, Carron, P, Poulsen, AEF, Jaremko, JL, Conaghan, PG & Østergaard, M 2021, 'Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods', Seminars in Arthritis and Rheumatism, vol. 51, no. 4, pp. 940-945. https://doi.org/10.1016/j.semarthrit.2021.05.006

TY - JOUR

T1 - Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

AU - Wetterslev, Marie

AU - Lambert, Robert GW

AU - Maksymowych, Walter P.

AU - Eshed, Iris

AU - Pedersen, Susanne J.

AU - Bird, Paul

AU - Stoenoiu, Maria S.

AU - Krabbe, Simon

AU - Mathew, Ashish J.

AU - Foltz, Violaine

AU - Gandjbakhch, Frédérique

AU - Paschke, Joel

AU - De Marco, Gabriele

AU - Marzo-Ortega, Helena

AU - Carron, Philippe

AU - Poulsen, Anna EF

AU - Jaremko, Jacob L.

AU - Conaghan, Philip G.

AU - Østergaard, Mikkel

PY - 2021/8

Y1 - 2021/8

N2 - Objective: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis. Methods: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS). Results: In exercises 3–4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58–0.65 (WIPE-osteitis), 0.10–0.88 (HIMRISS-osteitis) and for status/change 0.38–0.72/0.52–0.60 (WIPE-synovitis/effusion) and 0.68–0.89/0.78–0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS. Conclusion: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.

AB - Objective: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis. Methods: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS). Results: In exercises 3–4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58–0.65 (WIPE-osteitis), 0.10–0.88 (HIMRISS-osteitis) and for status/change 0.38–0.72/0.52–0.60 (WIPE-synovitis/effusion) and 0.68–0.89/0.78–0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS. Conclusion: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.

KW - HIMRISS

KW - Hip

KW - MRI-WIPE

KW - OMERACT

KW - Spondyloarthritis

KW - Whole-body MRI

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JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

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ER -

Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

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Keywords

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