Arthritis and enthesitis in the hip and pelvis region in spondyloarthritis - OMERACT validation of two whole-body MRI methods

Marie Wetterslev*, Robert GW Lambert, Walter P. Maksymowych, Iris Eshed, Susanne J. Pedersen, Paul Bird, Maria S. Stoenoiu, Simon Krabbe, Ashish J. Mathew, Violaine Foltz, Frédérique Gandjbakhch, Joel Paschke, Gabriele De Marco, Helena Marzo-Ortega, Philippe Carron, Anna EF Poulsen, Jacob L. Jaremko, Philip G. Conaghan, Mikkel Østergaard

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Objective: To validate reliability, correlation and responsiveness of two whole-body MRI scores for the hip/pelvis region in spondyloarthritis. Methods: Assessment of hip/pelvis inflammation in 4 multi-reader exercises using the OMERACT MRI Whole-body score for Inflammation in Peripheral joints and Entheses (MRI-WIPE) and Hip Inflammation Magnetic Resonance Imaging Scoring System (HIMRISS). Results: In exercises 3–4 (11/20 cases, respectively; 9 readers) reliability was mostly good for the 3 best calibrated readers. Median pairwise single-measure ICC for status were 0.58–0.65 (WIPE-osteitis), 0.10–0.88 (HIMRISS-osteitis) and for status/change 0.38–0.72/0.52–0.60 (WIPE-synovitis/effusion) and 0.68–0.89/0.78–0.85 (HIMRISS-synovitis/effusion). SRM was 1.23 for WIPE-osteitis, while lower for WIPE-synovitis/effusion and HIMRISS. Conclusion: MRI-WIPE and HIMRISS may after further validation be useful in future spondyloarthritis trials.

Original languageEnglish
Pages (from-to)940-945
Number of pages6
JournalSeminars in Arthritis and Rheumatism
Volume51
Issue number4
DOIs
StatePublished - Aug 2021

Funding

FundersFunder number
CARE Arthritis Limited
National Institute for Health and Care Research
Leeds Biomedical Research Centre

    Keywords

    • HIMRISS
    • Hip
    • MRI-WIPE
    • OMERACT
    • Spondyloarthritis
    • Whole-body MRI

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