Arterial Wall function is associated with cognitive performance primarily in elderly with type 2 diabetes

Ramit Ravona-Springer, Salo Haratz, David Tanne, James Schmeidler, Shai Efrati, Clive Rosendorff, Michal Schnaider Beeri, Jeremy M. Silverman

Research output: Contribution to journalArticlepeer-review

Abstract

Regression analyses compared 41 type 2 diabetes (T2D) and 131 non-T2D cognitively normal elderly males on the associations of arterial wall function measures [large artery elasticity index (LAEI), small artery elasticity index (SAEI), systemic vascular resistance (SVR), and total vascular impedance (TVI)] with cognitive performance (memory, language, and executive functions), controlling for socio-demographic and cardiovascular factors. Higher LAEI and lower TVI were significantly associated with better executive functions performance in T2D but not in non-T2D subjects. Lower TVI was more associated with better language performance in T2D. Results suggest that arterial wall function is associated with cognition in T2D.

Original languageEnglish
Pages (from-to)687-693
Number of pages7
JournalJournal of Alzheimer's Disease
Volume44
Issue number2
DOIs
StatePublished - 2015

Keywords

  • Arterial wall function
  • cognitive function
  • large artery elasticity index
  • total vascular impedance
  • type 2 diabetes

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