Arterial elasticity in cardiovascular disease: Focus on hypertension, metabolic syndrome and diabetes

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Arterial stiffness is an independent risk factor for premature cardiovascular morbidity and mortality that can be evaluated by noninvasive methods and can be reduced by good clinical management. The present chapter examines the association between arterial stiffness and cardiovascular risk factors including hypertension, metabolic syndrome, diabetes, advanced renal failure, hypercholesterolemia and obesity. The mechanisms responsible for the structural and functional modifications of the arterial wall are also described. We deal with parameters related to arterial compliance, focusing on two of them, pulse wave velocity and the augmentation index, useful in rapid assessment of arterial compliance by the bedside. Data that highlight the role of aortic pulse wave velocity and the augmentation index as independent factors in predicting fatal and nonfatal cardiovascular events in different populations are briefly presented. A number of lifestyle changes and traditional antihypertensive agents that improve arterial compliance are finally discussed. Novel therapies, such as statins, thiazolidindinediones, phosphodiesterase inhibitors and inhibitors or breakers of advanced glycation end product cross-links between colagen and elastin hold substantial promise.

Original languageEnglish
Title of host publicationCardiovascular Diabetology
Subtitle of host publicationClinical, Metabolic and Inflammatory Facets
EditorsEnrique Fisman, Alexander Tenenbaum
Pages65-81
Number of pages17
DOIs
StatePublished - 2008

Publication series

NameAdvances in Cardiology
Volume45
ISSN (Print)0065-2326

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