Aromatic short peptide architectonics: Assembly and engineering

Kai Tao*, Haoran Wu, Lihi Adler-Abramovich, Jiahao Zhang, Xinyuan Fan, Yunxiao Wang, Yan Zhang, Syed A.M. Tofail, Deqing Mei, Junbai Li, Ehud Gazit

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Since the report of diphenylalanine (FF) peptide self-assembly into discrete nanostructures in 2003, aromatic short peptide architectonics have been extensively studied globally and exhibiting tremendous application potentials in diverse fields. In this occasion of the 20th anniversary of the FF self-assembly nanotechnology, the key achievements in the development of bioinspired supramolecular peptide technology are comprehensively reviewed. In particular, we discuss self-organization of aromatic short peptides into low-dimensional dots moving on to ripening to diverse architectures and microfabrication into large-scale, highly-ordered arrays. Consequent optical, mechanical, electrical, catalytic and biomedical characteristics of these supramolecular architectures are also discussed. Challenges in aromatic short peptide architectonics are assessed and several perspectives for future exploitation are proposed.

Original languageEnglish
Article number101240
JournalProgress in Materials Science
StatePublished - Apr 2024


FundersFunder number
China-Israel Cooperative Scientific Research3-18130, 2022YFE0100800
Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Province2022R01001
Open Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems
National Natural Science Foundation of China52175551
National Key Research and Development Program of China


    • Aromatic short peptides
    • Bioinspired supramolecular architectures
    • Molecular manufacturing
    • Self-assembly and arraying


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