Arginine-Presenting Peptide Hydrogels Decorated with Hydroxyapatite as Biomimetic Scaffolds for Bone Regeneration

Moumita Ghosh, Michal Halperin-Sternfeld, Irena Grigoriants, Jaehun Lee, Ki Tae Nam, Lihi Adler-Abramovich

Research output: Contribution to journalArticlepeer-review

Abstract

Hydrogels are promising candidates for biomimetic scaffolds of the extracellular matrix in tissue engineering applications. However, their use in bone tissue engineering is limited due to their low mechanical properties. In this study, we designed and synthesized multicomponent peptide-based hydrogels composed of fluorenyl-9-methoxycarbonyl diphenylalanine (FmocFF), which contributed to the rigidity and stability of the hydrogel, and Fmoc-arginine (FmocR), which mediated high affinity to hydroxyapatite (HAP) due to the arginine moiety. The new hydrogels composed of nanometric fibril networks were decorated with HAP and demonstrated high mechanical strength with a storage modulus of up to 29 kPa. In addition, the hydrogels supported cell adhesion and in vitro cell viability. These properties suggest using these multicomponent organic-inorganic hydrogels as functional biomaterials for improved bone regeneration.

Original languageEnglish
Pages (from-to)3541-3550
Number of pages10
JournalBiomacromolecules
Volume18
Issue number11
DOIs
StatePublished - 13 Nov 2017

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