Area-Specific Amblyopic Effects in Human Occipitotemporal Object Representations

Y. Lerner, P. Pianka, B. Azmon, H. Leiba, C. Stolovitch, A. Loewenstein, M. Harel, T. Hendler, R. Malach*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia - a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functional activations in early retinotopic areas. Here we report the surprising finding of a selective object-related abnormality in high-order occipitotemporal cortex. Specifically, we found that face-related cortical areas show a severe disconnection from the amblyopic eye, while building-related regions remain essentially normal. The selectivity of the deficit highlights the differential computations performed in the different object-related areas and is compatible with the suggested association of face regions with analysis of fine detail.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages7
JournalNeuron
Volume40
Issue number5
DOIs
StatePublished - 4 Dec 2003

Funding

FundersFunder number
Israel Science Foundation77/00
Tel Aviv University8009

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