TY - JOUR
T1 - Area-Specific Amblyopic Effects in Human Occipitotemporal Object Representations
AU - Lerner, Y.
AU - Pianka, P.
AU - Azmon, B.
AU - Leiba, H.
AU - Stolovitch, C.
AU - Loewenstein, A.
AU - Harel, M.
AU - Hendler, T.
AU - Malach, R.
N1 - Funding Information:
The authors thank E. Okon for technical assistance; Y. Assaf and I. Goldberg for assistance in running the experiments; I. Levy, U. Hasson, and S. Gilaie-Dotan for comments. The work was funded by ISF grant 77/00, Adams Super Center for brain studies, Tel Aviv University grant and Center of Excellence grant 8009.
PY - 2003/12/4
Y1 - 2003/12/4
N2 - The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia - a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functional activations in early retinotopic areas. Here we report the surprising finding of a selective object-related abnormality in high-order occipitotemporal cortex. Specifically, we found that face-related cortical areas show a severe disconnection from the amblyopic eye, while building-related regions remain essentially normal. The selectivity of the deficit highlights the differential computations performed in the different object-related areas and is compatible with the suggested association of face regions with analysis of fine detail.
AB - The role of early visual experience in the establishment of human high-order visual areas is poorly understood. Here we investigated this issue using human amblyopia - a developmental visual disorder, which manifests a central vision (acuity) deficit. Previous fMRI studies of amblyopes have described abnormal functional activations in early retinotopic areas. Here we report the surprising finding of a selective object-related abnormality in high-order occipitotemporal cortex. Specifically, we found that face-related cortical areas show a severe disconnection from the amblyopic eye, while building-related regions remain essentially normal. The selectivity of the deficit highlights the differential computations performed in the different object-related areas and is compatible with the suggested association of face regions with analysis of fine detail.
UR - http://www.scopus.com/inward/record.url?scp=0346367074&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(03)00720-7
DO - 10.1016/S0896-6273(03)00720-7
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0346367074
SN - 0896-6273
VL - 40
SP - 1023
EP - 1029
JO - Neuron
JF - Neuron
IS - 5
ER -