TY - JOUR
T1 - Are Voltage Sensors Really Embedded in Muscarinic Receptors?
AU - Cohen-Armon, Malka
N1 - Publisher Copyright:
© 2023 by the author.
PY - 2023/4
Y1 - 2023/4
N2 - Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor, acting as a voltage sensor. However, this explanation is inconsistent with the results of experiments measuring acetylcholine binding to muscarinic receptors in brain synaptoneurosomes. According to these results, the gating of the voltage-dependent sodium channel (VDSC) acts as the voltage sensor, generating activation of Go-proteins in response to membrane depolarization, and this modulates the affinity of muscarinic receptors for their cholinergic agonists.
AB - Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor, acting as a voltage sensor. However, this explanation is inconsistent with the results of experiments measuring acetylcholine binding to muscarinic receptors in brain synaptoneurosomes. According to these results, the gating of the voltage-dependent sodium channel (VDSC) acts as the voltage sensor, generating activation of Go-proteins in response to membrane depolarization, and this modulates the affinity of muscarinic receptors for their cholinergic agonists.
KW - Go-proteins
KW - muscarinic receptors
KW - synaptoneurosomes
KW - voltage-dependent muscarinic receptors’ signaling
KW - voltage-dependent sodium channels
UR - http://www.scopus.com/inward/record.url?scp=85158021527&partnerID=8YFLogxK
U2 - 10.3390/ijms24087538
DO - 10.3390/ijms24087538
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C2 - 37108699
AN - SCOPUS:85158021527
SN - 1661-6596
VL - 24
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 8
M1 - 7538
ER -