Are Voltage Sensors Really Embedded in Muscarinic Receptors?

Malka Cohen-Armon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor, acting as a voltage sensor. However, this explanation is inconsistent with the results of experiments measuring acetylcholine binding to muscarinic receptors in brain synaptoneurosomes. According to these results, the gating of the voltage-dependent sodium channel (VDSC) acts as the voltage sensor, generating activation of Go-proteins in response to membrane depolarization, and this modulates the affinity of muscarinic receptors for their cholinergic agonists.

Original languageEnglish
Article number7538
JournalInternational Journal of Molecular Sciences
Volume24
Issue number8
DOIs
StatePublished - Apr 2023

Keywords

  • Go-proteins
  • muscarinic receptors
  • synaptoneurosomes
  • voltage-dependent muscarinic receptors’ signaling
  • voltage-dependent sodium channels

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