Are Voltage Sensors Really Embedded in Muscarinic Receptors?

Malka Cohen-Armon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Unexpectedly, the affinity of the seven-transmembrane muscarinic acetylcholine receptors for their agonists is modulated by membrane depolarization. Recent reports attribute this characteristic to an embedded charge movement in the muscarinic receptor, acting as a voltage sensor. However, this explanation is inconsistent with the results of experiments measuring acetylcholine binding to muscarinic receptors in brain synaptoneurosomes. According to these results, the gating of the voltage-dependent sodium channel (VDSC) acts as the voltage sensor, generating activation of Go-proteins in response to membrane depolarization, and this modulates the affinity of muscarinic receptors for their cholinergic agonists.

Original languageEnglish
Article number7538
JournalInternational Journal of Molecular Sciences
Issue number8
StatePublished - Apr 2023


  • Go-proteins
  • muscarinic receptors
  • synaptoneurosomes
  • voltage-dependent muscarinic receptors’ signaling
  • voltage-dependent sodium channels


Dive into the research topics of 'Are Voltage Sensors Really Embedded in Muscarinic Receptors?'. Together they form a unique fingerprint.

Cite this