Are Solitary Breast Papillomas Entirely Benign?

Haim Gutman*, Jacob Schachter, Nir Wasserberg, Itzchak Shechtman, Franklin Greiff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Hypothesis: Solitary breast papillomas are potentially malignant and are associated with a higher risk of breast cancer. Design: Retrospective review of all pathological reports containing breast papilloma (1983-2000) and review of selected specimens. Setting: Tertiary, referral, university-affiliated medical center. Participants: Ninety-five women with a breast specimen containing a papilloma or papillomatosis. Patients with overt papillary carcinoma without papilloma were excluded. Intervention: All histopathological characteristics of the papilloma and the surrounding tissue were noted. The incidence of malignant and other proliferative histopathological findings were analyzed, comparing solitary ductal papilloma cases to multiple papilloma cases. The Fisher exact test and χ2 test were applied for statistical analysis. Main Outcome Measures: Surgical removal of solitary ductal papillomas should include margins wide enough to secure removal of any proliferative tissue within or around the papilloma and to enable thorough evaluation of the risk for future breast cancer. Results: Solitary papillomas were associated with breast carcinoma in 7 patients (10%) in this series. An additional 9% (n = 6) presented with invasive or noninvasive carcinoma within the papilloma. Atypical papilloma was noted in 6% of patients (n = 4). The risk of associated malignancy was not significantly different between solitary ductal papilloma and multiple papilloma. Conclusion: Increased risk of breast cancer is associated with all forms of papilloma.

Original languageEnglish
Pages (from-to)1330-1333
Number of pages4
JournalArchives of Surgery
Volume138
Issue number12
DOIs
StatePublished - Dec 2003

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