Are estrogen receptors alpha detectable in normal and abnormal thyroid tissue?

Michael Vaiman, Youlian Olevson, Judith Sandbank, Liliana Habler, Sergei Zehavi, Alex Kessler

Research output: Contribution to journalArticlepeer-review

Abstract

The aims of this study is to evaluate the presence of estrogen receptors alpha (ERa) in thyroid lesions and to assess the practicality of this test in view of numerous disagreements on the subject. Immunohisto-chemical stains were performed for ERa, for the evaluation of immunoreactivity in 296 pathological thyroid tissue samples. We evaluated the intensity of the nuclear and cytoplasmatic staining and the spread of the stain over the sample. Thirty cases of the breast cancer served as a control group. None of the histological thyroid samples showed immunoreactivity for ERa. No difference was found between the various lesions in regard to this absence. The ERa rate of expression in the breast cancer samples was 60%. The ERa is undetectable in the histological samples of benign and malignant thyroid lesions. Further investigation is necessary in the laboratory immunohisto-chemical workup in order to exclude a possibility of nonspecific staining.

Original languageEnglish
Pages (from-to)1753-1757
Number of pages5
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume267
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • Carcinomas
  • Estrogen receptors
  • Immunoreactivity
  • Thyroid gland

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