TY - JOUR
T1 - Aprindine-induced polymorphous ventricular tachycardia
AU - Scagliotti, Daniel
AU - Strasberg, Boris
AU - Hai, Hamid A.
AU - Kehoe, Richard
AU - Rosen, Kenneth
N1 - Funding Information:
From the Section of Cardiology, Department of Medicine, Abraham Lincoln School of Medicine, University of Illinois College of Medicine, Chicago, Illinois and the Northwestern Memorial Hospital, Northwestern Medical School, Chicago, Illinois. This manuscript was supported in part by Institutional Training Grant HL 07387 and Research Grants HL 18794 and HL 23566 from the National Institutes of Health, Bethesda, Maryland and a grant from the Bane Estate, Chicago, Illinois. Manuscript received June 30, 1981; revised manuscript received October 20, 1981, accepted October 27, 1981.
PY - 1982/4/1
Y1 - 1982/4/1
N2 - Five cases of aprindine-induced polymorphous ventricular tachycardia (torsade de pointes) are presented. In four cases, polymorphous ventricular tachycardia appeared after the oral administration of aprindine and in one patient after the intravenous administration of 400 mg of aprindine. One patient had mild hypokalemia at the time of polymorphous ventricular tachycardia so that a direct cause and effect relation between the drug and the tachycardia cannot be established. All five patients manifested Q-T prolongation and recurrent syncope due to polymorphous ventricular tachycardia. In all five, polymorphous ventricular tachycardia subsided once administration of aprindine was discontinued.
AB - Five cases of aprindine-induced polymorphous ventricular tachycardia (torsade de pointes) are presented. In four cases, polymorphous ventricular tachycardia appeared after the oral administration of aprindine and in one patient after the intravenous administration of 400 mg of aprindine. One patient had mild hypokalemia at the time of polymorphous ventricular tachycardia so that a direct cause and effect relation between the drug and the tachycardia cannot be established. All five patients manifested Q-T prolongation and recurrent syncope due to polymorphous ventricular tachycardia. In all five, polymorphous ventricular tachycardia subsided once administration of aprindine was discontinued.
UR - http://www.scopus.com/inward/record.url?scp=0019982220&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(82)90059-5
DO - 10.1016/0002-9149(82)90059-5
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AN - SCOPUS:0019982220
SN - 0002-9149
VL - 49
SP - 1297
EP - 1300
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 5
ER -