Appraisal of the PIBD-classes Criteria: A Multicentre Validation

Oren Ledder, Micol Sonnino, Liron Birimberg-Schwartz, Johanna C. Escher, Richard K. Russell, Esther Orlanski-Meyer, Manar Matar, Amit Assa, Raffi Lev Tzion, Eyal Shteyer, Anne Griffiths, Dan Turner

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: The PIBD-classes criteria were developed to standardise the classification of children with inflammatory bowel disease [IBD], from Crohn's disease [CD], through IBD-unclassified [IBD-U], to typical ulcerative colitis [UC]. We aimed to further validate the criteria and to explore possible modifications. METHODS: This was a multicentre retrospective cohort study of children diagnosed with IBD with at least 1 year of follow-up. Clinical, radiological, endoscopic, and histological data were recorded at diagnosis and latest follow-up, as well as the 23 items of the PIBD-classes criteria. The PIBD-classes criteria were assessed for redundant items, and a simplified algorithm was proposed and validated on the original derivation cohort from which the PIBD-classes algorithm was derived. RESULTS: Of the 184 included children [age at diagnosis 13 ± 3 years, 55% males], 122 [66%] were diagnosed by the physician with CD, 17 [9%] with IBD-U, and 45 [25%] with UC. There was high agreement between physician-assigned and PIBD-classes generated diagnosis for CD [93%; eight patients moved to IBD-U] and for UC [84%; six moved to IBD-U and one to CD]. A simplified version of the algorithm with only 19 items is suggested, with comparable performance to the original algorithm [81% sensitivity and 81% specificity vs 78% and 83% for UC; and 79% and 95% vs 80% and 95% for CD, respectively]. CONCLUSIONS: The PIBD-classes algorithm is a useful tool to facilitate standardised objective classification of IBD subtypes in children. A modified version of the PIBD-classes maintains accuracy of classification with a simplified algorithm.

Original languageEnglish
Pages (from-to)1672-1679
Number of pages8
JournalJournal of Crohn's and Colitis
Volume14
Issue number12
DOIs
StatePublished - 2 Dec 2020

Keywords

  • IBD-unclassified
  • classification
  • paediatric

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