Applying Human Cells to Organogenesis and Transplantation

Benjamin Dekel*, Yair Reisner

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Organ transplantation has been one of themajor medical advances of the past 30years; however, it is becoming increasinglyapparent that the supply of organs is limitedand will not improve with currentmedical practice. Organogenesis representsan alternative to combat organ shortage.Organogenesis of complex tissues,such as the kidney, requires a coordinatedsequential transformation process, with individualstages involving time-dependentexpression of cell-cell, cell-matrix, andcell-signal interactions in three dimensions.Embryonic precursor tissues arecomposed of functionally diverse stem/progenitor cell types that are organized inspatially complex arrangements. Thetheme of temporal-spatial patterning ofprogenitor cell interactions is programmedin precursor tissues leading to theirgrowth and development. Indeed, recentdata pinpoints a window of time in humanand pig kidney organogenesis thatmay be optimal for transplantation intomature recipients. "Window" transplantsare defined by their remarkable ability togrow, differentiate and undergo vascularization,achieving successful organogenesisof urine-producing miniature kidneys withno evidence of trans-differentiation intonon-renal cell types, lack of tumorigenicityand reduced immunogenicity, compared toadult counterparts. In contrast, "non-window"transplants (earlier or later in gestation)can respectively form teratomas orare more prone to immune rejection, andare both less suitable for organogenesis.Thus, when organogenesis can be successfullyachieved in situ, it may provide theoptimal approach for replacement of organs.

Original languageEnglish
Title of host publicationModern Biopharmaceuticals
Subtitle of host publicationDesign, Development and Optimization
PublisherWiley-VCH Verlag GmbH
Pages353-373
Number of pages21
Volume1
ISBN (Print)352731184X, 9783527311842
DOIs
StatePublished - 5 Feb 2008
Externally publishedYes

Keywords

  • Cartilage
  • Immunogenicity
  • Propagation
  • Transplantation
  • Xenotransplants

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