Applications of lentiviral vectors in molecular imaging

Sushmita Chatterjee, Abhijit De*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Molecular imaging provides the ability of simultaneous visual and quantitative estimation of long term gene expression directly from living organisms. To reveal the kinetics of gene expression by imaging method, often sustained expression of the transgene is required. Lentiviral vectors have been extensively used over last fifteen years for delivery of a transgene in a wide variety of cell types. Lentiviral vectors have the well known advantages such as sustained transgene delivery through stable integration into the host genome, the capability of infecting non-dividing and dividing cells, broad tissue tropism, a reasonably large carrying capacity for delivering therapeutic and reporter gene combinations. Additionally, they do not express viral proteins during transduction, have a potentially safe integration site profile, and a relatively easy system for vector manipulation and infective viral particle production. As a result, lentiviral vector mediated therapeutic and imaging reporter gene delivery to various target organs areas holds promise for the future treatment. In this review, we have conducted a brief survey of important lentiviral vector developments in diverse biomedical fields including reproductive biology.

Original languageEnglish
Pages (from-to)835-853
Number of pages19
JournalFrontiers in Bioscience - Landmark
Issue number6
StatePublished - 1 Jun 2014
Externally publishedYes


  • Bioluminescence
  • Lentiviral vector
  • Molecular imaging
  • Reporter gene
  • Review


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