Application of the concept synthetic lethality toward anticancer therapy: A promise fulfilled?

Dan Canaani*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Back in 1997, a suggestion to apply the concept of synthetic lethality towards the development of selective, less toxic, cancer drugs and anticancer targets, was brought forward. The availability of large scale synthetic, low-molecular-weight chemical libraries seemed to lend itself to the concept. Human/mouse genome-wide siRNAs and shRNA-expressing libraries allowing high throughput screening for target genes synergistic lethal with defined human cancer aberrations, also raised high hopes of a soon to be established selective therapy. Sixteen years later, the major experimental aspects relating to the implementation of this more focused approach to cancer drug discovery, is briefly and critically reviewed.

Original languageEnglish
Pages (from-to)59-65
Number of pages7
JournalCancer Letters
Volume352
Issue number1
DOIs
StatePublished - 28 Sep 2014

Keywords

  • Cancer therapy
  • Chemical synthetic lethality
  • Genetic synthetic lethality
  • Oncogenes
  • RNAi
  • Tumor suppressor genes

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