TY - JOUR
T1 - Application of MR morphologic, diffusion tensor, and perfusion imaging in the classification of brain tumors using machine learning scheme
AU - Shrot, Shai
AU - Salhov, Moshe
AU - Dvorski, Nir
AU - Konen, Eli
AU - Averbuch, Amir
AU - Hoffmann, Chen
N1 - Publisher Copyright:
© 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Purpose: While MRI is the modality of choice for the assessment of patients with brain tumors, differentiation between various tumors based on their imaging characteristics might be challenging due to overlapping imaging features. The purpose of this study was to apply a machine learning scheme using basic and advanced MR sequences for distinguishing different types of brain tumors. Methods: The study cohort included 141 patients (41 glioblastoma, 38 metastasis, 50 meningioma, and 12 primary central nervous system lymphoma). A computer-assisted classification scheme, combining morphologic MRI, perfusion MRI, and DTI metrics, was developed and used for tumor classification. The proposed multistep scheme consists of pre-processing, ROI definition, features extraction, feature selection, and classification. Feature subset selection was performed using support vector machines (SVMs). Classification performance was assessed by leave-one-out cross-validation. Given an ROI, the entire classification process was done automatically via computer and without any human intervention. Results: A binary hierarchical classification tree was chosen. In the first step, selected features were chosen for distinguishing glioblastoma from the remaining three classes, followed by separation of meningioma from metastasis and PCNSL, and then to discriminate PCNSL from metastasis. The binary SVM classification accuracy, sensitivity and specificity for glioblastoma, metastasis, meningiomas, and primary central nervous system lymphoma were 95.7, 81.6, and 91.2%; 92.7, 95.1, and 93.6%; 97, 90.8, and 58.3%; and 91.5, 90, and 96.9%, respectively. Conclusion: A machine learning scheme using data from anatomical and advanced MRI sequences resulted in high-performance automatic tumor classification algorithm. Such a scheme can be integrated into clinical decision support systems to optimize tumor classification.
AB - Purpose: While MRI is the modality of choice for the assessment of patients with brain tumors, differentiation between various tumors based on their imaging characteristics might be challenging due to overlapping imaging features. The purpose of this study was to apply a machine learning scheme using basic and advanced MR sequences for distinguishing different types of brain tumors. Methods: The study cohort included 141 patients (41 glioblastoma, 38 metastasis, 50 meningioma, and 12 primary central nervous system lymphoma). A computer-assisted classification scheme, combining morphologic MRI, perfusion MRI, and DTI metrics, was developed and used for tumor classification. The proposed multistep scheme consists of pre-processing, ROI definition, features extraction, feature selection, and classification. Feature subset selection was performed using support vector machines (SVMs). Classification performance was assessed by leave-one-out cross-validation. Given an ROI, the entire classification process was done automatically via computer and without any human intervention. Results: A binary hierarchical classification tree was chosen. In the first step, selected features were chosen for distinguishing glioblastoma from the remaining three classes, followed by separation of meningioma from metastasis and PCNSL, and then to discriminate PCNSL from metastasis. The binary SVM classification accuracy, sensitivity and specificity for glioblastoma, metastasis, meningiomas, and primary central nervous system lymphoma were 95.7, 81.6, and 91.2%; 92.7, 95.1, and 93.6%; 97, 90.8, and 58.3%; and 91.5, 90, and 96.9%, respectively. Conclusion: A machine learning scheme using data from anatomical and advanced MRI sequences resulted in high-performance automatic tumor classification algorithm. Such a scheme can be integrated into clinical decision support systems to optimize tumor classification.
KW - Advance MRI
KW - Artificial intelligence
KW - Computer
KW - Diagnosis
UR - http://www.scopus.com/inward/record.url?scp=85064513880&partnerID=8YFLogxK
U2 - 10.1007/s00234-019-02195-z
DO - 10.1007/s00234-019-02195-z
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AN - SCOPUS:85064513880
SN - 0028-3940
VL - 61
SP - 757
EP - 765
JO - Neuroradiology
JF - Neuroradiology
IS - 7
ER -