TY - JOUR
T1 - Application of comparative genomic hybridization in search for genetic aberrations in fibroadenomas of the breast
AU - Amiel, A.
AU - Kaufman, Z.
AU - Goldstein, E.
AU - Bruchim, R. Bar Sade
AU - Kidron, D.
AU - Gaber, E.
AU - Fejgin, M. D.
PY - 2003/4/15
Y1 - 2003/4/15
N2 - We applied a comparative genomic hybridization (CGH) technique to paraffin-embedded tissue samples taken from fibroadenomas, benign breast tumors, to detect possible numerical and unbalanced genetic changes. We compared the results to those from previous cytogenetic studies of fibroadenomas. In concurrence with previous cytogenetic studies of fibroadenomas, we detected genetic aberrations in chromosomes 4-6, 8-13, 16, 18, 19, 20, and 22. In addition, with the CGH technique we were able to find two new aberrations, 15q+ and 16p-. Because these aberrations have also been reported to be present in breast cancer, the importance of this finding is yet to be determined.
AB - We applied a comparative genomic hybridization (CGH) technique to paraffin-embedded tissue samples taken from fibroadenomas, benign breast tumors, to detect possible numerical and unbalanced genetic changes. We compared the results to those from previous cytogenetic studies of fibroadenomas. In concurrence with previous cytogenetic studies of fibroadenomas, we detected genetic aberrations in chromosomes 4-6, 8-13, 16, 18, 19, 20, and 22. In addition, with the CGH technique we were able to find two new aberrations, 15q+ and 16p-. Because these aberrations have also been reported to be present in breast cancer, the importance of this finding is yet to be determined.
UR - http://www.scopus.com/inward/record.url?scp=0344406211&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(02)00833-6
DO - 10.1016/S0165-4608(02)00833-6
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AN - SCOPUS:0344406211
SN - 0165-4608
VL - 142
SP - 145
EP - 148
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -
