Application of a novel prenatal vertical cranial biometric measurement can improve accuracy of microcephaly diagnosis in utero

Z. Leibovitz*, C. Shiran, K. Haratz, M. Tamarkin, L. Gindes, L. Schreiber, G. Malinger, L. Ben-Sira, D. Lev, I. Shapiro, H. Bakry, B. Weizman, A. Zreik, D. Kidron, S. Egenburg, A. Arad, T. Lerman-Sagie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective To construct a reference range for a new vertical measurement of the fetal head and to assess whether its combination with fetal head circumference (HC) can prevent the misdiagnosis of microcephaly in fetuses with an acrocephalic-like head deformation. Methods A new vertical cranial biometric measurement was defined: the foramen magnum-to-cranium distance (FCD), measured between the foramen magnum and the upper inner cranial border along the posterior wall of the brainstem. The measurement was performed in a precise mid-sagittal plane using a three-dimensional multiplanar display of a sagittally acquired sonographic volume of the fetal head. The normal reference range was developed by measuring 396 healthy fetuses of low-risk singleton pregnancies between 15 and 40 gestational weeks. This reference was applied to 25 fetuses with microcephaly diagnosed prenatally (Fmic) based on HC ≥ 3 SD below the mean for gestational age. We determined an optimal FCD cut-off for combination with HC to detect all cases found with microcephaly at birth (micB), while excluding the fetuses with normal head circumference at birth (NHCB), who were described postnatally as having an acrocephalic-like cranial deformation. Results In the healthy singleton fetuses, FCD increased with gestational age, with a quadratic equation providing an optimal fit to the data (adjusted R2 = 0.934). The measurement could be assessed in 95.2% of cases. Of the 25 cases diagnosed with Fmic prenatally, on the basis of HC alone, 14 were micB and 11 were NHCB. We observed FCD below the mean - 2SD for gestational age in all 14 micB cases, but in only four of the 11 NHCB cases (P < 0.003). An acrocephalic-like cranial deformation was described at birth in five of the seven NHCB cases with normal FCD. The mean ± SD FCD Z-score of the micB cases was significantly lower (P < 0.001) than that of the false-positive ones: -3.85 ± 0.96 SD and -1.59 ± 1.45 SD, respectively. Based on HC measurement alone, the positive predictive value (PPV) was 56%. Combination of the HC and FCD criteria raised the PPV to 78%, decreasing the number of false positives from 11 to four, without missing any of the 14 micB cases. Conclusions Fetal vertical cranial biometric assessment in the mid-sagittal plane is feasible and correlates well with gestational age. In our series, a vertical cranial deformation was a frequent cause of a false Fmic diagnosis made on the basis of HC alone. Combination of the new vertical cranial biometric measurement with HC measurement can exclude these cases and thus improve diagnostic accuracy for Fmic.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalUltrasound in Obstetrics and Gynecology
Issue number5
StatePublished - 1 May 2016
Externally publishedYes


  • craniosynostosis
  • fetal microcephaly
  • molding
  • prenatal reference chart
  • ultrasound
  • vertical cranial biometry


Dive into the research topics of 'Application of a novel prenatal vertical cranial biometric measurement can improve accuracy of microcephaly diagnosis in utero'. Together they form a unique fingerprint.

Cite this