Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures

Ruth Farkas; Shlomo Ben-Efraim; Yosef Manor; Israel Zan-Bar; Abraham Klajman

doi:10.1007/BF01742310

Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures

Ruth Farkas, Shlomo Ben-Efraim, Yosef Manor, Israel Zan-Bar, Abraham Klajman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Cancer Immunology, Immunotherapy
Volume	34
Issue number	3
DOIs	https://doi.org/10.1007/BF01742310
State	Published - May 1991

Keywords

B cell leukemia
CD8 marker
T cell

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF01742310

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title = "Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures",

abstract = "Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.",

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author = "Ruth Farkas and Shlomo Ben-Efraim and Yosef Manor and Israel Zan-Bar and Abraham Klajman",

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AU - Farkas, Ruth

AU - Ben-Efraim, Shlomo

AU - Manor, Yosef

AU - Zan-Bar, Israel

AU - Klajman, Abraham

PY - 1991/5

Y1 - 1991/5

N2 - Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.

AB - Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.

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KW - CD8 marker

KW - T cell

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Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures

Abstract

Keywords

UN SDGs

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