Appearance of the T-cell marker CD8 on B chronic lymphatic leukemia cells in long-term cultures

Ruth Farkas, Shlomo Ben-Efraim, Yosef Manor, Israel Zan-Bar, Abraham Klajman

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term cultures of highly purified B chronic lymphatic leukemia cells (B-CLL), were established. The B-CLL lymphocytes acquired the CD8 T cell marker in long-term cultures while still retaining their surface immunoglobulins. In confirmation of previous results, the cultured B-CLL lymphocytes released factor(s) into the culture medium that suppressed the allogeneic mixed-lymphocyte reaction. No correlation was found between the appearance of the CD8 T cell surface marker and onset of suppressor activity.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalCancer Immunology, Immunotherapy
Volume34
Issue number3
DOIs
StatePublished - May 1991

Keywords

  • B cell leukemia
  • CD8 marker
  • T cell

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