We analyzed 14 published studies, in which anticonvulsants and placebo were compared in a double-blind cross-over manner, in order to determine it and to what extent, placebo effects exist in the treatment of epilepsy. This meta-analysis included 206 patients with various seizure disorders. Compared to baseline values, placebo decreased seizure frequency by 5%. The response to placebo was independent from the seizure form. Patients who had frequent seizures were as likely to respond to placebo as those who had seizures only rarely. The placebo effect was higher (14%) in patients treated for short periods.
|Number of pages||8|
|Journal||New Trends in Clinical Neuropharmacology|
|State||Published - 1991|