Apparent placebo effect in epilepsy

V. E. Drory, A. D. Korczyn

Research output: Contribution to journalArticlepeer-review


We analyzed 14 published studies, in which anticonvulsants and placebo were compared in a double-blind cross-over manner, in order to determine it and to what extent, placebo effects exist in the treatment of epilepsy. This meta-analysis included 206 patients with various seizure disorders. Compared to baseline values, placebo decreased seizure frequency by 5%. The response to placebo was independent from the seizure form. Patients who had frequent seizures were as likely to respond to placebo as those who had seizures only rarely. The placebo effect was higher (14%) in patients treated for short periods.

Original languageEnglish
Pages (from-to)49-56
Number of pages8
JournalNew Trends in Clinical Neuropharmacology
Issue number2
StatePublished - 1991
Externally publishedYes


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