Apoptosis inhibitor, survivin, in posterior uveal melanoma: Comparison among primary tumors, tumors resistant to brachytherapy, tumors with liver metastases, and liver metastases

Guy J. Ben Simon, Adi Abulafia, Jacob Pe'er

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To study the expression of survivin, an apoptosis inhibitor protein, in human posterior uveal melanoma. Methods: Specimens were divided according to eyes with tumors that were enucleated primarily, those resistant to brachytherapy, eyes from patients with known liver metastases, and liver metastases. Results: There was only low expression of survivin in uveal melanoma. No difference in survivin positive cell counts per high power field (PCC/HPF) were found among tumors that were enucleated primarily (n = 33), tumors with previous brachytherapy (n = 29), tumors with liver metastases (n = 12) or liver metastases (n = 18). Corresponding counts were 11.8 (±14.3), 11.8 (±16.8), 7.1 (±11.2), and 4.7 (±8.8) in the four groups, respectively (p > 0.05). Half of the liver metastases showed no staining for survivin. Twenty patients (24%) had tumor-related death at the end of follow-up. Conclusions: Survivin is expressed in posterior uveal melanomas that were treated by enucleation, as well as in tumors that were previously treated with brachytherapy or liver metastases; however, its expression by immunostaining did not seem with correlate with the tumor biological activity.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalCurrent Eye Research
Volume31
Issue number3
DOIs
StatePublished - Mar 2006
Externally publishedYes

Keywords

  • Brachytherapy
  • Inhibitors of apoptosis
  • Liver metastases
  • Survivin
  • Uveal melanoma

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