TY - JOUR
T1 - Apoptosis in breast cancer
AU - Werner, Haim
AU - Oh, Youngman
AU - Roberts, Charles T.
N1 - Funding Information:
Work in the laboratory of H.W. is supported by grants from the Israel Cancer Association, The Israel Academy of Sciences, The U.S.-Israel Binational Science Foundation, The Recanati Foundation, The Israel Cancer Research Fund (New York) and the Fogarty International Center (NIH, USA). H.W. is the recipient of a Guastalla Fellowship from the Rashi Foundation, Israel. Work in the laboratory of Y.O. is supprted by grants from the U.S. Department of Defense and the American Cancer Society. Work in the laboratory of C.T.R. is supported by grants from the NIDDK, the NICHD, the Fogarty International Center (NIH), and the M.J. Murdock Charitable Trust.
PY - 2001
Y1 - 2001
N2 - It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.
AB - It has become increasingly clear that apoptosis plays a critical role in mammary gland development and is an important facet of mammary carcinogenesis. The critical role of apoptosis in breast cancer derives from: (1) the influence of BRCA and p53 mutations that result in continued proliferation and increased genetic instability in precancerous mammary epithelial cells that would otherwise be subject to growth arrest and/or apoptotic death: (2) the apoptosis-modulating effects of many hormones and growth factors that had independently been demonstrated to influence breast cancer development and progression; and (3) the potential diagnostic value of factors such as IGF-I and Bcl-2, whose predictive value may reflect their anti-apoptotic effects. The continuing elucidation of the molecular pathways involved in apoptosis and their regulatory mechanisms will provide new avenues for improved diagnosis and treatment of breast cancer.
UR - http://www.scopus.com/inward/record.url?scp=35448964294&partnerID=8YFLogxK
U2 - 10.1016/S1566-3124(01)06001-1
DO - 10.1016/S1566-3124(01)06001-1
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AN - SCOPUS:35448964294
SN - 1566-3124
VL - 6
SP - 1
EP - 22
JO - Advances in Cell Aging and Gerontology
JF - Advances in Cell Aging and Gerontology
IS - C
ER -
