Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant

N. Donin, D. Katzenelson, J. Ravia, J. Hiss, G. Schiby, S. Kay, J. Sinai, M. Michowitz, J. Leibovici

Research output: Contribution to journalArticlepeer-review

Abstract

The possibility that apoptosis and/or cell proliferation have a role in tumour progression in a murine T cell lymphoma was tested. The model consisted of the comparison of primary (PT) and metastatic tumour (MT) cells. The PT cells, but not the MT cells displayed a very pronounced tendency for spontaneous apoptosis. Proliferative capacity of MT cells was lower than that of PT cells, suggesting that it does not contribute to the metastatic phenotype in this system. Release from apoptosis does however, probably, play a role in the aggressiveness of the lymphoma.

Original languageEnglish
Pages (from-to)214-220
Number of pages7
JournalApoptosis : an international journal on programmed cell death
Volume2
Issue number2
DOIs
StatePublished - 1997

Keywords

  • AKR lymphoma
  • Apoptosis
  • Cell proliferative capacity
  • Metastatic potential

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