Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant

N. Donin; D. Katzenelson; J. Ravia; J. Hiss; G. Schiby; S. Kay; J. Sinai; M. Michowitz; J. Leibovici

doi:10.1023/A:1026424817392

Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant

N. Donin, D. Katzenelson, J. Ravia, J. Hiss, G. Schiby, S. Kay, J. Sinai, M. Michowitz, J. Leibovici^*

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The possibility that apoptosis and/or cell proliferation have a role in tumour progression in a murine T cell lymphoma was tested. The model consisted of the comparison of primary (PT) and metastatic tumour (MT) cells. The PT cells, but not the MT cells displayed a very pronounced tendency for spontaneous apoptosis. Proliferative capacity of MT cells was lower than that of PT cells, suggesting that it does not contribute to the metastatic phenotype in this system. Release from apoptosis does however, probably, play a role in the aggressiveness of the lymphoma.

Original language	English
Pages (from-to)	214-220
Number of pages	7
Journal	Apoptosis : an international journal on programmed cell death
Volume	2
Issue number	2
DOIs	https://doi.org/10.1023/A:1026424817392
State	Published - 1997

Keywords

AKR lymphoma
Apoptosis
Cell proliferative capacity
Metastatic potential

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10.1023/A:1026424817392

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title = "Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant",

abstract = "The possibility that apoptosis and/or cell proliferation have a role in tumour progression in a murine T cell lymphoma was tested. The model consisted of the comparison of primary (PT) and metastatic tumour (MT) cells. The PT cells, but not the MT cells displayed a very pronounced tendency for spontaneous apoptosis. Proliferative capacity of MT cells was lower than that of PT cells, suggesting that it does not contribute to the metastatic phenotype in this system. Release from apoptosis does however, probably, play a role in the aggressiveness of the lymphoma.",

keywords = "AKR lymphoma, Apoptosis, Cell proliferative capacity, Metastatic potential",

author = "N. Donin and D. Katzenelson and J. Ravia and J. Hiss and G. Schiby and S. Kay and J. Sinai and M. Michowitz and J. Leibovici",

note = "Funding Information: The authors wish to acknowledge the partial support of this study by the Hammer Fund for Medical Research.",

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doi = "10.1023/A:1026424817392",

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Donin, N, Katzenelson, D, Ravia, J, Hiss, J, Schiby, G, Kay, S, Sinai, J, Michowitz, M & Leibovici, J 1997, 'Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant', Apoptosis : an international journal on programmed cell death, vol. 2, no. 2, pp. 214-220. https://doi.org/10.1023/A:1026424817392

TY - JOUR

T1 - Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant

AU - Donin, N.

AU - Katzenelson, D.

AU - Ravia, J.

AU - Hiss, J.

AU - Schiby, G.

AU - Kay, S.

AU - Sinai, J.

AU - Michowitz, M.

AU - Leibovici, J.

N1 - Funding Information: The authors wish to acknowledge the partial support of this study by the Hammer Fund for Medical Research.

PY - 1997

Y1 - 1997

N2 - The possibility that apoptosis and/or cell proliferation have a role in tumour progression in a murine T cell lymphoma was tested. The model consisted of the comparison of primary (PT) and metastatic tumour (MT) cells. The PT cells, but not the MT cells displayed a very pronounced tendency for spontaneous apoptosis. Proliferative capacity of MT cells was lower than that of PT cells, suggesting that it does not contribute to the metastatic phenotype in this system. Release from apoptosis does however, probably, play a role in the aggressiveness of the lymphoma.

AB - The possibility that apoptosis and/or cell proliferation have a role in tumour progression in a murine T cell lymphoma was tested. The model consisted of the comparison of primary (PT) and metastatic tumour (MT) cells. The PT cells, but not the MT cells displayed a very pronounced tendency for spontaneous apoptosis. Proliferative capacity of MT cells was lower than that of PT cells, suggesting that it does not contribute to the metastatic phenotype in this system. Release from apoptosis does however, probably, play a role in the aggressiveness of the lymphoma.

KW - AKR lymphoma

KW - Apoptosis

KW - Cell proliferative capacity

KW - Metastatic potential

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JO - Apoptosis : an international journal on programmed cell death

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IS - 2

ER -

Apoptosis, cell proliferation and in vivo biological behaviour of primary and metastatic tumour cells of an AKR lymphoma variant

Abstract

Keywords

UN SDGs

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