Apolipoprotein B levels predict platelet-dependent thrombosis in patients with coronary artery disease

Michael Shechter, C. Noel Bairey Merz, Maura J. Paul-Labrador, Prediman K. Shah, Sanjay Kaul*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated plasma apolipoprotein B is a known risk factor for atherosclerotic coronary artery disease (CAD), however its relationship to arterial thrombosis is unexplored. We prospectively assessed apolipoprotein B and platelet-dependent thrombosis (PDT) in 42 CAD patients (37 men, 5 women, mean age 68 ± 9 years), by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 min using an ex vivo perfusion (Badimon) chamber. PDT was significantly correlated with apolipoprotein B (r = 0.41, p = 0.009), intracellular magnesium levels (r = -0.46, p = 0.003) fasting blood glucose (r = 0.47, p = 0.002), and total cholesterol (r = 0.43, p = 0.006). PDT did not correlate with serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I or fibrinogen levels. These findings suggest that the positive relationship of elevated apolipoprotein B to CAD may be, in part, related to its prothrombotic effects. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalCardiology
Volume92
Issue number3
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Apolipoproteins
  • Coronary disease
  • Platelets
  • Thrombosis

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