TY - JOUR
T1 - Apolipoprotein B levels predict platelet-dependent thrombosis in patients with coronary artery disease
AU - Shechter, Michael
AU - Bairey Merz, C. Noel
AU - Paul-Labrador, Maura J.
AU - Shah, Prediman K.
AU - Kaul, Sanjay
PY - 1999
Y1 - 1999
N2 - Elevated plasma apolipoprotein B is a known risk factor for atherosclerotic coronary artery disease (CAD), however its relationship to arterial thrombosis is unexplored. We prospectively assessed apolipoprotein B and platelet-dependent thrombosis (PDT) in 42 CAD patients (37 men, 5 women, mean age 68 ± 9 years), by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 min using an ex vivo perfusion (Badimon) chamber. PDT was significantly correlated with apolipoprotein B (r = 0.41, p = 0.009), intracellular magnesium levels (r = -0.46, p = 0.003) fasting blood glucose (r = 0.47, p = 0.002), and total cholesterol (r = 0.43, p = 0.006). PDT did not correlate with serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I or fibrinogen levels. These findings suggest that the positive relationship of elevated apolipoprotein B to CAD may be, in part, related to its prothrombotic effects. Copyright (C) 2000 S. Karger AG, Basel.
AB - Elevated plasma apolipoprotein B is a known risk factor for atherosclerotic coronary artery disease (CAD), however its relationship to arterial thrombosis is unexplored. We prospectively assessed apolipoprotein B and platelet-dependent thrombosis (PDT) in 42 CAD patients (37 men, 5 women, mean age 68 ± 9 years), by exposing porcine aortic media to their flowing unanticoagulated venous blood for 5 min using an ex vivo perfusion (Badimon) chamber. PDT was significantly correlated with apolipoprotein B (r = 0.41, p = 0.009), intracellular magnesium levels (r = -0.46, p = 0.003) fasting blood glucose (r = 0.47, p = 0.002), and total cholesterol (r = 0.43, p = 0.006). PDT did not correlate with serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein A-I or fibrinogen levels. These findings suggest that the positive relationship of elevated apolipoprotein B to CAD may be, in part, related to its prothrombotic effects. Copyright (C) 2000 S. Karger AG, Basel.
KW - Apolipoproteins
KW - Coronary disease
KW - Platelets
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=0033287789&partnerID=8YFLogxK
U2 - 10.1159/000006964
DO - 10.1159/000006964
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C2 - 10754344
AN - SCOPUS:0033287789
SN - 0008-6312
VL - 92
SP - 151
EP - 155
JO - Cardiology
JF - Cardiology
IS - 3
ER -