APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

Pazit Beckerman; Katalin Susztak

doi:10.1016/j.molmed.2018.05.008

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

Pazit Beckerman, Katalin Susztak^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Chronic kidney disease (CKD) affects millions of people and constitutes a major health and financial burden worldwide. People of African descent are at an increased risk of developing kidney disease, which is mostly explained by two variants in the Apolipoprotein L1 (APOL1) gene that are found only in people of west African origin. It is hypothesized that these variants were genetically selected due to the protection they afford against African sleeping sickness, caused by the parasite Trypanosoma brucei. Targeting mutant APOL1 could have substantial therapeutic potential for treating kidney disease. In this review, we will describe the intriguing interplay between microbiology, genetics, and kidney disease as revealed in APOL1-associated kidney disease, discuss APOL1-induced cytotoxicity and its therapeutic implications.

Original language	English
Pages (from-to)	682-695
Number of pages	14
Journal	Trends in Molecular Medicine
Volume	24
Issue number	8
DOIs	https://doi.org/10.1016/j.molmed.2018.05.008
State	Published - Aug 2018
Externally published	Yes

Keywords

Apolipoprotein 1
chronic kidney disease
genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.molmed.2018.05.008

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abstract = "Chronic kidney disease (CKD) affects millions of people and constitutes a major health and financial burden worldwide. People of African descent are at an increased risk of developing kidney disease, which is mostly explained by two variants in the Apolipoprotein L1 (APOL1) gene that are found only in people of west African origin. It is hypothesized that these variants were genetically selected due to the protection they afford against African sleeping sickness, caused by the parasite Trypanosoma brucei. Targeting mutant APOL1 could have substantial therapeutic potential for treating kidney disease. In this review, we will describe the intriguing interplay between microbiology, genetics, and kidney disease as revealed in APOL1-associated kidney disease, discuss APOL1-induced cytotoxicity and its therapeutic implications.",

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AB - Chronic kidney disease (CKD) affects millions of people and constitutes a major health and financial burden worldwide. People of African descent are at an increased risk of developing kidney disease, which is mostly explained by two variants in the Apolipoprotein L1 (APOL1) gene that are found only in people of west African origin. It is hypothesized that these variants were genetically selected due to the protection they afford against African sleeping sickness, caused by the parasite Trypanosoma brucei. Targeting mutant APOL1 could have substantial therapeutic potential for treating kidney disease. In this review, we will describe the intriguing interplay between microbiology, genetics, and kidney disease as revealed in APOL1-associated kidney disease, discuss APOL1-induced cytotoxicity and its therapeutic implications.

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APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease

Abstract

Keywords

UN SDGs

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