Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5′-nucleotidase (P-5′-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on theassociation of B19-HPV-related aplastic crisis with P-5′-N deficiency.
- Aplastic crisis
- B19 parvovirus
- Molecular hybridization
- Pyrimidine-5′-nucleotidase deficiency