Aplastic crisis due to human b19 parvovirus infection in red cell pyrimidine-5′ -nucleotidase deficiency

Gideon Rechavi, Ami Vonsover, Yossef Manor, Fernando Mileguir, Ofer Shpilberg, George Kende, Frida Brok-Simoni, Matilda Mandel, Tamar Gotlieb-Stematski, Isaac Ben-Bassat, Bracha Ramot

Research output: Contribution to journalArticlepeer-review

Abstract

Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5′-nucleotidase (P-5′-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on theassociation of B19-HPV-related aplastic crisis with P-5′-N deficiency.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalActa Haematologica
Volume82
Issue number1
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Aplastic crisis
  • B19 parvovirus
  • Molecular hybridization
  • Pyrimidine-5′-nucleotidase deficiency

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