APC/β-catenin deregulation in desmoid tumors: Important implications for diagnosis, prognosis, and therapy

Chiara Colombo; Dina Lev

doi:10.1007/978-94-007-1685-8_4

APC/β-catenin deregulation in desmoid tumors: Important implications for diagnosis, prognosis, and therapy

Chiara Colombo^*, Dina Lev

^*Corresponding author for this work

University of Texas MD Anderson Cancer Center

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Understanding the molecular aberrations driving the inception and progression of desmoid tumors (DTs) is crucial to devising an effective management for these neoplasms. The APC/β-catenin pathway is known to be deregulated in DT. This chapter illuminates the molecular mechanisms of APC/β-catenin pathway signaling, elucidates the potential deregulations and mutations at play in DTs, and most importantly evaluates the possible implications of this pathway on DT diagnosis, prognosis, and therapy.

Original language	English
Title of host publication	Desmoid Tumors
Publisher	Springer Netherlands
Pages	29-46
Number of pages	18
ISBN (Electronic)	9789400716858
ISBN (Print)	9789400716841
DOIs	https://doi.org/10.1007/978-94-007-1685-8_4
State	Published - 1 Jan 2012
Externally published	Yes

Keywords

APC
Mutations
Prognostic biomarkers
Sequencing
Targeted therapy
β-Catenin

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10.1007/978-94-007-1685-8_4

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APC/β-catenin deregulation in desmoid tumors: Important implications for diagnosis, prognosis, and therapy

Abstract

Keywords

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