Anxiogenic effects of m-CPP in patients with panic disorder: Comparison to caffeine's anxiogenic effects

Ehud Klein, Joseph Zohar, Marilla F. Geraci, Dennis L. Murphy, Thomas W. Uhde*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The behavioral and neuroendocrine effects of meta-chlorophenylpiperazine (m-CPP), a serotonergic agonist, were compared with the effects of caffeine, an adenosine antagonist, in panic disorder patients. Patients with panic disorder were given single oral doses of 0.5 mg/kg m-CPP, 480 mg caffeine, and placebo on separate days under double-blind conditions. Both m-CPP and caffeine had significantly greater anxiogenic and panic-inducing effects than placebo, although caffeine produced nonsignificantly greater increases on all anxiety rating scales than m-CPP. Both m-CPP and caffeine produced significant equivalent increases in plasma cortisol concentrations, but only m-CPP produced plasma prolactin increases. These findings provide further evidence implicating both the serotonergic and adenosinergic receptor systems in the neurobiology of panic disorder.

Original languageEnglish
Pages (from-to)973-984
Number of pages12
JournalBiological Psychiatry
Volume30
Issue number10
DOIs
StatePublished - 15 Nov 1991
Externally publishedYes

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