Antithrombin III levels in preeclampsia

E. Aghai*, J. Brunstein, M. Quitt, H. Abramovici, P. Froom

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Antithrombin III (AT-III) activity was measured and compared in 29 patients with preeclampsia and 31 women with normal pregnancies. AT-III levels were 83 ± 25% in preeclamptic patients with > 5 g/l proteinuria compared with 102 ± 11% in the controls. Less severe proteinuria was not associated with decreased AT-III levels. Multivariate analysis revealed that the duration of pregnancy and the degree of proteinuria had an independent negative effect on AT-III levels. AT-III activity correlated poorly with platelet counts and blood pressure measurements. We conclude that urinary loss appears to be the major mechanisms of lower AT-III levels observed in our patients with preeclampsia.

Original languageEnglish
Pages (from-to)142-143
Number of pages2
JournalIsrael Journal of Medical Sciences
Volume26
Issue number3
StatePublished - 1990
Externally publishedYes

Keywords

  • antithrombin III
  • preeclampsia
  • proteinuria

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