Abstract
Antithrombin III (AT-III) activity was measured and compared in 29 patients with preeclampsia and 31 women with normal pregnancies. AT-III levels were 83 ± 25% in preeclamptic patients with > 5 g/l proteinuria compared with 102 ± 11% in the controls. Less severe proteinuria was not associated with decreased AT-III levels. Multivariate analysis revealed that the duration of pregnancy and the degree of proteinuria had an independent negative effect on AT-III levels. AT-III activity correlated poorly with platelet counts and blood pressure measurements. We conclude that urinary loss appears to be the major mechanisms of lower AT-III levels observed in our patients with preeclampsia.
Original language | English |
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Pages (from-to) | 142-143 |
Number of pages | 2 |
Journal | Israel Journal of Medical Sciences |
Volume | 26 |
Issue number | 3 |
State | Published - 1990 |
Externally published | Yes |
Keywords
- antithrombin III
- preeclampsia
- proteinuria