TY - JOUR
T1 - Antipyretic effectiveness of acetaminophen in febrile seizures
T2 - Ongoing prophylaxis versus sporadic usage
AU - Schnaiderman, D.
AU - Lahat, E.
AU - Sheefer, T.
AU - Aladjem, M.
PY - 1993/9
Y1 - 1993/9
N2 - A controlled clinical study compared the antipyretic effectiveness of acetaminophen administered at regular 4 h intervals (group 1, n=53) versus sproadic usage contingent upon a body temperature above 37.9°C (group 2, n=51) in 104 children presenting with simple febrile convulsions. The incidence of febrile episodes or temperature values were similar in spite of significantly larger amounts of acetaminophen administered to patients in group 1. Four and 4 children in groups 1 and 2, respectively, had a second episode of febrile seizures, in all of them within the first 24 h of admission. We conclude that the prophylactic administration of acetaminophen in children with febrile seizures is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of febrile seizures.
AB - A controlled clinical study compared the antipyretic effectiveness of acetaminophen administered at regular 4 h intervals (group 1, n=53) versus sproadic usage contingent upon a body temperature above 37.9°C (group 2, n=51) in 104 children presenting with simple febrile convulsions. The incidence of febrile episodes or temperature values were similar in spite of significantly larger amounts of acetaminophen administered to patients in group 1. Four and 4 children in groups 1 and 2, respectively, had a second episode of febrile seizures, in all of them within the first 24 h of admission. We conclude that the prophylactic administration of acetaminophen in children with febrile seizures is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of febrile seizures.
KW - Acetaminophen
KW - Febrile seizures
UR - http://www.scopus.com/inward/record.url?scp=0027218727&partnerID=8YFLogxK
U2 - 10.1007/BF01953992
DO - 10.1007/BF01953992
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AN - SCOPUS:0027218727
VL - 152
SP - 747
EP - 749
JO - Acta Paediatrica Hungarica
JF - Acta Paediatrica Hungarica
SN - 0340-6199
IS - 9
ER -