Antipyretic effectiveness of acetaminophen in febrile seizures: Ongoing prophylaxis versus sporadic usage

D. Schnaiderman, E. Lahat, T. Sheefer, M. Aladjem

Research output: Contribution to journalArticlepeer-review

Abstract

A controlled clinical study compared the antipyretic effectiveness of acetaminophen administered at regular 4 h intervals (group 1, n=53) versus sproadic usage contingent upon a body temperature above 37.9°C (group 2, n=51) in 104 children presenting with simple febrile convulsions. The incidence of febrile episodes or temperature values were similar in spite of significantly larger amounts of acetaminophen administered to patients in group 1. Four and 4 children in groups 1 and 2, respectively, had a second episode of febrile seizures, in all of them within the first 24 h of admission. We conclude that the prophylactic administration of acetaminophen in children with febrile seizures is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of febrile seizures.

Original languageEnglish
Pages (from-to)747-749
Number of pages3
JournalEuropean Journal of Pediatrics
Volume152
Issue number9
DOIs
StatePublished - Sep 1993

Keywords

  • Acetaminophen
  • Febrile seizures

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