Antipsychotic drug effects in a model of schizophrenic attentional disorder: A randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people

Jonathan H. Williams; Nigel A. Wellman; David P. Geaney; Philip J. Cowen; Joram Feldon; J. N.P. Rawlins

doi:10.1016/S0006-3223(95)00629-X

Antipsychotic drug effects in a model of schizophrenic attentional disorder: A randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people

Jonathan H. Williams^*, Nigel A. Wellman, David P. Geaney, Philip J. Cowen, Joram Feldon, J. N.P. Rawlins

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

We studied the effects of haloperidol (0.5 mg, intravenously) on latent inhibition in an auditory paradigm and two visual paradigms in healthy subjects. Haloperidol increased latent inhibition in one visual paradigm and tended to increase latent inhibition in an auditory task, compared to saline-injected controls. These results indicate that haloperidol can enhance the selectivity of attention. In contrast, previous studies have reported that acute schizophrenics show reduced latent inhibition.

Original language	English
Pages (from-to)	1135-1143
Number of pages	9
Journal	Biological Psychiatry
Volume	40
Issue number	11
DOIs	https://doi.org/10.1016/S0006-3223(95)00629-X
State	Published - 1 Dec 1996
Externally published	Yes

Keywords

attention
haloperidol
healthy volunteers
latent inhibition
randomized controlled trial
schizophrenia

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10.1016/S0006-3223(95)00629-X

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Antipsychotic drug effects in a model of schizophrenic attentional disorder: A randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people. / Williams, Jonathan H.; Wellman, Nigel A.; Geaney, David P. et al.
In: Biological Psychiatry, Vol. 40, No. 11, 01.12.1996, p. 1135-1143.

Research output: Contribution to journal › Article › peer-review

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Antipsychotic drug effects in a model of schizophrenic attentional disorder: A randomized controlled trial of the effects of haloperidol on latent inhibition in healthy people

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Keywords

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