@article{6d767d1e0a104c29911858d6e70eed38,
title = "Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background",
abstract = "The antiphospholipid syndrome (APS) is characterized by antiphospholipid antibodies (aPL) and vascular brain disease which is often associated with dementia. We examined the neurodegenerative pathological processes underlying APS by inducing APS in a transgenic animal model of Alzheimer's disease. Female C57B6/SJL mice carrying the APP695SWE mutation (Tg2576) and wild-type (wt) controls were immunized with β2-glycoprotein-I (APS mice) or adjuvant alone (controls) at 4 months of age. At the age of 8 months the APP-APS mice developed high levels of aPL associated with motor hypoactivity in a staircase test (p<0.03 by t-test) and impaired performance in the cognitive T-maze (p<0.02 for main effect of treatment by repeated measures ANOVA) relative to APP-CFA mice and controls. wt-APS and wt-control did not differ significantly in their behavior or cognition. Histological studies revealed mature plaques only in the APP-APS group which also had higher amyloid load and number of activated microglia compared to all other groups. The results indicate a significant interaction between APP genotype and the induction of APS on a female background. The mechanisms involved may also be important in human APS-AD co-morbidity.",
keywords = "Activated microglia, Alzheimer's disease, Amyloid plaque, Amyloid precursor protein, Antiphospholipid syndrome, Behavior, Cognition, Transgenic mouse",
author = "Aviva Katzav and Achinoam Faust-Socher and Filip Kvapil and Michaelson, {Daniel M.} and Miri Blank and Pick, {Chaim G.} and Yehuda Shoenfeld and Korczyn, {Amos D.} and Joab Chapman",
note = "Funding Information: This study was performed in partial fulfillment of the requirements for a PhD degree of Aviva Katzav, and in partial fulfillment of the requirement for a MD degree of A. Faust-Socher, Sackler Faculty of Medicine, Tel Aviv University, Israel. This study was supported by a grant from the Harry Stern National Center for Alzheimer's Disease and Related Disorders (The Israel national Institute for Psychobiology), by the Joseph Sagol Neuroscience Center and by the Seiratzki Chair of Neurology, Tel Aviv University, by the Wolfson Foundation, and by the Israel Ministry of Health fund. The appropriate institutional approval for all animal experiments was obtained, Tel Aviv University Animal Research Committee approval number M-04-005.",
year = "2011",
month = feb,
doi = "10.1016/j.neurobiolaging.2009.02.007",
language = "אנגלית",
volume = "32",
pages = "272--279",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "2",
}