Antiphospholipid Syndrome and Vaccines

Miri Blank, Paola Cruz-Tapias

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Antiphospholipid syndrome (APS) is an autoimmune multisystemic disease associated with recurrent fetal loss, thromboembolic phenomena, thrombocytopenia, and neurological, cardiac, and dermatological involvement. APS is characterized by the presence of antiphospholipid antibodies, which bind negatively charged phospholipids, mainly through β2-glycoprotein I (β2GPI). Tetanus toxoid (TTd) is a potent exotoxin produced by the bacterium Clostridium tetani. DNA hepatitis B virus (HBV) vaccination was given to 85 healthy students and, 1 month post-vaccination, a minority of individuals showed changes in IgG or IgM anticardiolipin and anti-β2GPI antibodies or lupus anticoagulant. Toplak et al. reported the presence of anti-β2GPI antibodies in 15% of 92 healthy medical workers up to 6 months post-influenza vaccination. Molecular mimicry has been proposed as one of the mechanisms by which experimental APS can occur in association with pathogens.

Original languageEnglish
Title of host publicationVaccines and Autoimmunity
Number of pages6
ISBN (Electronic)9781118663721
ISBN (Print)9781118663431
StatePublished - 1 Jan 2014
Externally publishedYes


  • Anti-β2-glycoprotein I (β2GPI)antibodies
  • Antiphospholipid syndrome (APS)
  • DNA hepatitis B virus (HBV) vaccination
  • Post-influenza vaccination
  • Tetanus toxoid (TTd) vaccine


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