TY - JOUR
T1 - Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis
AU - Adler, Arnon
AU - Afek, Arnon
AU - Levy, Yair
AU - Keren, Gad
AU - George, Jacob
PY - 2009
Y1 - 2009
N2 - Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.
AB - Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.
UR - http://www.scopus.com/inward/record.url?scp=61449174691&partnerID=8YFLogxK
U2 - 10.1038/ncpcardio1436
DO - 10.1038/ncpcardio1436
M3 - מאמר
AN - SCOPUS:61449174691
VL - 6
SP - 215
EP - 218
JO - Nature Reviews Cardiology
JF - Nature Reviews Cardiology
SN - 1759-5002
IS - 3
ER -