Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis

Arnon Adler, Arnon Afek, Yair Levy, Gad Keren, Jacob George*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalNature Clinical Practice Cardiovascular Medicine
Volume6
Issue number3
DOIs
StatePublished - 2009
Externally publishedYes

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