Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis

Arnon Adler; Arnon Afek; Yair Levy; Gad Keren; Jacob George

doi:10.1038/ncpcardio1436

Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis

Arnon Adler, Arnon Afek, Yair Levy, Gad Keren, Jacob George^*

^*Corresponding author for this work

Tel Aviv Sourasky Medical Center

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.

Original language	English
Pages (from-to)	215-218
Number of pages	4
Journal	Nature Clinical Practice Cardiovascular Medicine
Volume	6
Issue number	3
DOIs	https://doi.org/10.1038/ncpcardio1436
State	Published - 2009
Externally published	Yes

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title = "Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis",

abstract = "Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.",

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AU - Adler, Arnon

AU - Afek, Arnon

AU - Levy, Yair

AU - Keren, Gad

AU - George, Jacob

PY - 2009

Y1 - 2009

N2 - Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.

AB - Background: A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina. Investigations: Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG. Diagnosis: Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel. Management: The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.

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Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis

Abstract

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