Antinuclear autoantibodies in uveitis

I. Hundert, R. Bakimer, H. Amital-Teplizki, H. Slor, Y. Yassur, A. Palestine, R. B. Nussenblatt, Y. Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

We have studied 44 sera of patients with uveitis, and controls for the presence of ANF and other antinuclear antibodies (ss-DNA, ds-DNA, Poly (I), Poly (G), RNP, Sm, histones) and for the presence of a common anti-DNA idiotype (16/6 Id) employing the ELISA method. Various incidences of antinuclear antibodies were found in sera of patients with uveitis. The uveitis specimens were found to have high titers of autoantibodies to ss-DNA, ds-DNA, Poly (I), histones and Poly (G). High titers of anti-Sm antibodies were detected only in 9% of the uveitis patients, which is markedly lower than the reported percentage of anti-Sm antibodies in SLE. No significant differences were found in the incidence of antinuclear antibodies between sera of patients with localized uveitis and uveitis concomitant with a systemic disorder. Similarly, no relationship was found between location of uveitis (anterior versus posterior) and autoantibody profile. Our results imply that despite considering uveitis as a specific organ malady, it should be regarded serologically as an autoimmune condition.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalClinical and Experimental Rheumatology
Volume7
Issue number3
StatePublished - 1989
Externally publishedYes

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